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Cannata et al. Mini-invasive Surg 2020;4:53 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2020.41

Review Open Access

Percutaneous mitral valve repair in acute mitral
regurgitation: case report and review of the

literature

Francesco Cannata , Jorge Sanz-Sánchez , Mauro Chiarito 2,3, Martina Briani , Fabio Fazzari , Letizia
1,2
3
2,4
1,2
F. Bertoldi , Giuseppe Ferrante , Elena Corrada , Renato M. Bragato , Giulio G. Stefanini , Paolo A.
2,4
2,3
2,3
2,4
1,2
Pagnotta , Bernhard Reimers , Damiano Regazzoli 2,3
2,3
3
1 Non-invasive Cardiology Unit, Cardio Center, Humanitas Clinical and Research Center - IRCCS, Rozzano-Milan 20089, Italy.
2 Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan 20090, Italy.
3 Interventional Cardiology Unit, Cardio Center, Humanitas Clinical and Research Center - IRCCS, Rozzano-Milan 20089, Italy.
4 Coronary Care Unit, Cardio Center, Humanitas Clinical and Research Center - IRCCS, Rozzano-Milan 20089, Italy.
Correspondence to: Dr. Damiano Regazzoli, Interventional Cardiology Unit, Cardio Center, Humanitas Research Hospital,
Rozzano-Milano 20089, Italy. E-mail: damiano.regazzolilancini@humanitas.it
How to cite this article: Cannata F, Sanz-Sánchez J, Chiarito M, Briani M, Fazzari F, Bertoldi LF, Ferrante G, Corrada E, Bragato RM,
Stefanini GG, Pagnotta PA, Reimers B, Regazzoli D. Percutaneous mitral valve repair in acute mitral regurgitation: case report and
review of the literature. Mini-invasive Surg 2020;4:53. http://dx.doi.org/10.20517/2574-1225.2020.41
Received: 28 Apr 2020 First Decision: 23 Jun 2020 Revised: 3 Jul 2020 Accepted: 14 Jul 2020 Published: 15 Aug 2020
Academic Editor: Giulio Belli Copy Editor: Cai-Hong Wang Production Editor: Jing Yu

Abstract
Acute mitral regurgitation is a heterogeneous and life-threatening pathology, with severe hemodynamic
consequences and extremely adverse outcomes. Traditionally, the definitive treatment is prompt surgical
intervention after hemodynamic stabilization. Nowadays, however, percutaneous repair of mitral valve with
MitraClip device has emerged as a safe and effective therapeutic option. Evidences in this field are still scarce.
Hereby, we report the case of an 82-year-old woman with lateral ST-elevation myocardial infarction determining
severe acute mitral regurgitation (MR) with an asymmetric leaflet tethering mechanism. Due to prohibitive
operative risk and unstable hemodynamic status, the patient underwent a successful urgent MitraClip procedure
with optimal reduction of MR and immediate hemodynamic improvement. Moreover, we provide a review of
the available literature regarding the echocardiographic assessment of acute MR, results of published cases and
possible management of this complex pathology.

Keywords: MitraClip, edge-to-edge, percutaneous mitral valve repair, acute mitral regurgitation, acute myocardial
infarction, cardiogenic shock, papillary muscle rupture

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
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