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Tropiano et al. Mini-invasive Surg 2024;8:17 https://dx.doi.org/10.20517/2574-1225.2024.41 Page 13 of 15

In conclusion, our findings, even if to be considered preliminary because of the small numbers and the
short follow-up, confirm the excellent local control achieved with IRT and the low occurrence of classical
toxicities (septal and alar perforations) with the anatomic implantation thus supporting the adoption of
[41]
anatomic IRT as treatment of choice for a primary lesion in NV-SCC without bone invasion , as recently
suggested by the Italian Society of Otolaryngology. The present result also points to the possibility of
reducing skin toxicity, therefore further improving cosmetic outcomes in these patients.

DECLARATIONS
Authors’ contributions
Study conception and design: Tropiano P, Bussu F, Riu FG, Rijken JA
Data acquisition: Tondo A, Varrucciu S, Tropiano P
Quality control of data and algorithms: Tagliaferri L, Varrucciu S, Gallus R, Mattiucci GC, De Ridder M,
Rijken JA, Scheurleer WFJ, D’Aviero A, Fionda B, Riu FG, Bussu F
Data analysis and interpretation: Tropiano P, Bussu F, Tondo A, Varrucciu S
Manuscript preparation: Tropiano P, Bussu F, Tondo A
Manuscript editing: Tropiano P, Bussu F, Tondo A, Riu FG
Manuscript review: Tagliaferri L, Varrucciu S, Gallus R, Mattiucci GC, De Ridder M, Rijken JA, Scheurleer
WFJ, D’Aviero A, Fionda B, Riu FG, Bussu F

Availability of data and materials
The data that support the findings of this study are available from the corresponding author upon
reasonable request.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
The current study was done in accordance with the ethical standards of each institutional committee on
human experimentation, the Declaration of Helsinki. Data were analyzed with an observational
retrospective design, and in this case, mandatory ethical approval is not required under Italian law (GU No.
76 31 March 2008). Informed consent was obtained from the patients for the procedure.

Consent for publication
Patients’ written informed consent for publication was obtained.

Copyright
© The Author(s) 2024.

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