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Tropiano et al. Mini-invasive Surg 2024;8:17 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2024.41

Original Article Open Access

From applicator-based (Paris system) implantations

to rhinoseptoplasty: the concept of anatomic
implantation for interventional radiotherapy in

squamous cell carcinoma of the nasal vestibule.
Short term results in a monoinstitutional series

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Paolo Tropiano , Luca Tagliaferri , Andrea Tondo 1 , Simona Varrucciu , Roberto Gallus , Gian Carlo
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Mattiucci , Mischa De Ridder , Johannes A. Rijken , W. F. Julius Scheurleer , Andrea D’Aviero , Bruno
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Fionda , Francesco Giuseppe Riu , Francesco Bussu 1,7
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Otolaryngology Division, University Hospital of Sassari, Sassari 07100, Italy.
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Department of Diagnostic Imaging, Oncological Radiotherapy and Hematology, Agostino Gemelli IRCCS University Polyclinic
Foundation, Catholic University of Sacred Heart, Rome 00168, Italy.
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Otolaryngology, Mater Olbia Hospital, Olbia 07026, Italy.
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Radiation Oncology, Mater Olbia Hospital, Olbia 07026, Italy.
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Department of Radiation Oncology, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands.
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Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands.
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Department of Medical, Surgical and Experimental Science, University of Sassari, Sassari 07100, Italy.
Correspondence to: Dr. Andrea Tondo, Otolaryngology Division, University Hospital of Sassari, Viale San Pietro n. 43, Plesso
“Stecca Bianca”, Scala C, Piano 1, Sassari 07100, Italy. E-mail: andreatd1105@gmail.com
How to cite this article: Tropiano P, Tagliaferri L, Tondo A, Varrucciu S, Gallus R, Mattiucci GC, De Ridder M, Rijken JA,
Scheurleer WFJ, D’Aviero A, Fionda B, Riu FG, Bussu F. From applicator-based (Paris system) implantations to rhinoseptoplasty:
the concept of anatomic implantation for interventional radiotherapy in squamous cell carcinoma of the nasal vestibule. Short
term results in a monoinstitutional series. Mini-invasive Surg 2024;8:17. https://dx.doi.org/10.20517/2574-1225.2024.41
Received: 7 May 2024 First Decision: 21 Aug 2024 Revised: 28 Aug 2024 Accepted: 6 Sep 2024 Published: 9 Sep 2024
Academic Editors: Ehab Hanna, Giulio Belli Copy Editor: Pei-Yun Wang Production Editor: Pei-Yun Wang
Abstract
Aim: Interventional radiotherapy (IRT) is being increasingly advocated as the standard treatment for the primary
lesion in nasal vestibule squamous cell carcinoma (NV-SCC). The respect of the anatomical planes of the nose tip
during implantation has been hypothesized to reduce the classical IRT toxicities on the cartilages, such as septal
and even alar perforations. The present work describes a monoinstitutional series of NV-SCC treated with an IRT
technique that follows the above principle (anatomical implantation), with a focus on IRT toxicities.

Methods: All consecutive patients with nasal vestibule (NV) carcinoma treated between March 2022 and October

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
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