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Page 6 of 11             Riachi et al. Mini-invasive Surg 2023;7:14  https://dx.doi.org/10.20517/2574-1225.2022.120

               Table 2. Studies comparing RPD to Open PD
                                 EBL RPD  OR time        R0RR   POPF   CS-POPF  Morb.   CDS ≥   Mort.   LOS
                           N                     LN RPD
                           RPD   vs. OPD  RPD vs.   vs. OPD   RPD vs.  RPD vs.  RPD vs.   RPD vs.  III RPD  RPD vs.  RPD vs.
                Author           (mean   OPD (mean       OPD    OPD    OPD (%)  OPD   vs. OPD  OPD   OPD
                           vs. N                 (mean) (
                           OPD   in ml) (P in minutes)   P-value)  (%) (P- (%) (P- (P-  (%) (P- (%) (P- (%) (P- (days) (
                                 -value)  (P-value)      value)  value)  value)  value)  value)  value)  P-value)
                      [57]
                Zhou et al.  8 vs. 8  153 vs.   718 vs. 420    NR  87.5 vs.   50 vs.   0 vs. 12.5   25 vs. 75   NR  0 vs. 12.5   16.4 vs.
                                 210    (P = 0.011)      100    37.5    (NR)  (P =          (P =   24.3
                                 (P =                    (P =   (P =          0.05)         0.05)  (P =
                                 0.045)                  0.05)  0.05)                              0.04)
                Buchs et al. [58]  44 vs.   387 vs.   444 vs. 559   16.8 vs. 11   90.9 vs.   18 vs.   50 vs. 37.5  36.4 vs.   NR  4.5 vs.   13 vs. 14.6
                           39    827    (P < 0.01)  (P = 0.02) 81.5    20.5    (NR)  48.7   2.6
                                 (P < 0.01)              (P =   (P =          (0.27)        (P =   (P = 0.4)
                                                         0.45)  1.00)                       1.00)
                Chalikonda   30 vs.   485 vs.   476 vs. 366.4  NR  0 vs. 13    6.7 vs.   6.7 vs. 16.7  30 vs. 44   NR  1 vs. 0    9.8 vs.
                  [64]
                et al.     30    775                     (P =   16.7 (NR) (NR)  (P = 0.14)  (P =   13.3
                                 (P = 0.13) (P < 0.01)   0.02)                              0.09)  (P =
                                                                                                   0.043)
                     [59]
                Lai et al.  20 vs.   247 vs.   492 vs. 265    10 vs. 10    73.3 vs.   35 vs.   NR  50 vs.   NR  0 vs. 3    13.7 vs.
                           67    775    (P = 0.01)  (P = 0.99) 64.1    17.9    49.3         (P =   25.8
                                 (P =                    (P =   (P = 0.11)    (P =          0.43)
                                 0.03)                   0.92)                0.95)
                      [65]       *      *                **
                Chen et al.  60 vs.   400 vs.   410 vs. 323   13.6 vs.   94.7 vs.  13.3 vs.   8.3 vs. 15.0  35 vs. 40   11.7 vs.   1.7 vs. 2.5  20 vs. 25
                           120   500    (P < 0.01)  12.5    92.1    24.2    (NR)  (P =   13.3       (P < 0.01)
                                 (P < 0.01)      (P =    (P =   (P =          0.515)  (P =   (P =
                                                 0.350)  1.00)  0.09)                0.752)  1.00)
                        [54]
                Zureikat et al.  211 vs.  200 vs.   402 vs. 300   27.5 vs. 19   R1RR: 50  NR  13.74 vs.   NR  23.7 vs.   1.9 vs.   8 vs. 8
                           817   300    (P < 0.01)  (P < 0.01) vs. 31    9.04        23.9    2.89    (P =
                                 (P < 0.01)              (P <          (P = 0.04)    (P =   (P =   0.98)
                                                            ***
                                                         0.01)                       0.96)  0.46)
                Boggi et al. [49]  83 vs.   NR  527 vs. 425    37 vs. 36   87.5 vs.   33.8 vs.   18.1 vs. 5.6  73.5 vs.   18.1 vs.   2.4 vs. 0   17 vs. 14
                           36           (P < 0.01)  (P = 0.51) 54.5    16.7    (NR)  77.9    11.2 (NR) (P =   (P =
                                                         (P =   (P =          (P =          1.00)  0.06)
                                                         0.08)  0.06)         0.62)
                Wang et al. [63]  87 vs.   202 vs.   455 vs. 375    15 vs. 13    96.6 vs.   NR  8 vs. 12.6   43.7 vs.   9.1 vs. 8.0  0 vs. 0  24 vs. 24
                           87^   298    (P < 0.01)  (P < 0.01) 94.3    (P =   53.2    (NR)         (P =
                                 (P < 0.01)              (P =          0.456)  (P                  0.884)
                                                         0.363)               =0.612)
                Varley et al. [66]  133 vs.  200 vs.   393 vs. 432    NR  82% vs.   12 vs. 24   5 vs. 18    NR  24 vs. 28   3.8 vs.   8 vs. 10
                           149   500    (P < 0.01)       81%    (P =   (P < 0.01)    (P =   5.4    (P < 0.01)
                                 (P < 0.01)              (P =   0.013)               0.464)  (P =
                                                         0.851)                             0.52)
                      [67]
                Girgis et al.  163 vs.  250 vs.   402 vs. 421    31.9 vs.   82.5 vs.   NR  NR  NR  24.5 vs.   4.29 vs.   7 vs. 9
                           198   500    (P = 0.081)  25.9    82.3                    29.8    4.55    (P < 0.01)
                                 (P < 0.01)      (P < 0.01) (P =                     (P =   (P =
                                                         0/055)                      0.265)  0.908)
                    [62]
                Jin et al.  22 vs.   75 vs.   225 vs. 275    3.5 vs. 1    100 vs.   68.2 vs.   9.1 vs. 18.2   NR  9 vs. 4.5   NR  15 vs. 19
                           22^   300    (P = 0.294)  (P =   100 (NR) 68.2   (P =     (P =          (P =
                                 (P < 0.01)      0.205)         (NR)   0.0664)       1.00)         0.493)
                Mejia et al. [68]  102 vs.  321 vs.   353 vs. 212    24.2 vs.   66.7 vs.   4 vs. 0   4 vs. 0   14.7 vs.   9.3 vs.   3 vs. 2   7 vs. 11.8
                           54    378    (P < 0.01)  23.7    70    (NR)  (NR)  37.0 (NR) 5.9 (NR)  (NR)  (P < 0.01)
                                 (P =            (P = 780) (P =
                                 0.121)                  0.663)
                     [61]
                Shi et al.  187 vs.  297 vs.   279 vs. 298    16.6 vs.   94.7 vs.   NR  10.2 vs.   NR  NR  2.1 vs. 3.7  22.4 vs.
                           187^  415    (P = 0.02)  15.8    93         14.4                        26.1
                                 (P < 0.01)      (P =    (P -0.68)     (P = 0.09)           (P =   (P =
                                                 0.495)                                     0.47)  0.03)
                        [70]
                Nassour et al.  626 vs.  NR  NR  22 vs. 17    77 vs. 78  NR  NR  NR  NR     4 vs. 6    10 vs. 11
                           17,205                (P < 0.01) (NR)                            (P =   (P < 0.01)
                                                                                            0.061)
                Nassour et al. [69]  155 vs.  NR  NR  30 vs. 18    79 vs. 84  NR  NR  NR  NR  3.4 vs.   8 vs. 10
                           3,329                 (P < 0.01) (NR)                            2.6    (P < 0.01)
                                                                                            (P =
                                                                                            0.570)
                      [60]
                Shyr et al.  304 vs.   197 vs.   468 vs. 438    18 vs. 18    NR  NR  13 vs. 11.2   48.2 vs.   12.3 vs.   2.1 vs. 1.8   20 vs. 24
                           172   531    (P = 0.015)  (P =              (P =   56.8    8.3 (NR)  (P =   (P =
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