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Page 10 of 14                                                                              Farinha et al. Mini-invasive Surg 2023;7:38  https://dx.doi.org/10.20517/2574-1225.2023.50



                              Glybochko   Evaluate effectiveness of personalized 3D  Used time-based metrics and blood loss  None identified  Elasticity and density similar to real kidney  Can contribute to improvement of surgical
                                  [28]
                              et al.     printed models for pre-surgical planning                                                                                            skills and facilitate selection of optimal
                                                                                                                                                                             surgical tactics
                              Ohtake     Examine effectiveness of the model as a   Used Lickert-scale questionnaires to evaluate  None identified  Significant differences between novice and   Can be used daily as a training tool for LPN
                                  [33]
                              et al.     tool for practicing LPN             realism and utility as training tools                   expert performance
                                                                             Used GOALS to score performance                         Improvement in the learning curve
                                                                             Used procedure-specific metrics

                              Makiyama   Describe and validate a patient-specific   Visual analog scales to assess anatomical   None identified  Reproduced patient anatomy   Useful as a preoperative training tool
                                  [30]
                              et al.     simulator for laparoscopic surgery  integrity and utility and intraoperative                High scores in the utility of simulations and   Improvements still needed
                                                                             confidence during subsequent surgical                   surgeons’ intraoperative confidence
                                                                             procedures
                              Hung       Evaluate face, content, construct, and   Questionnaires to evaluate realism and   None identified  Differentiated performance of experts from   Although validated, several areas need
                                  [29]
                              et al.     concurrent validity                 usefulness for training                                 non-experts                             improvement, particularly with the teaching
                                                                             Used GEARS and computer-based                           Highly useful in training residents and fellows  of advanced technical skills
                                                                             performance metrics                                     but less so for experienced surgeons
                                                                                                                                     Inferior utility in training compared with
                                                                                                                                     porcine
                                                                                                                                     Scored high to teach surgical anatomy and
                                                                                                                                     procedure steps


                              CROMS: Clinically relevant outcome measures; GEARS: global evaluative assessment of robotic skills; GOALS: global operative assessment of operative skills; LPN: laparoscopic partial nephrectomy; NASA-TLX:
                              NASA-task load index; PN: partial nephrectomy; RALPN: robot assisted partial nephrectomy; RAPN: robot-assisted partial nephrectomy; TM: training model.




                              Although the preparation and use of 3D printed models were labor intensive, and monofilament sutures were recommended (e.g., braided sutures easily torn
                              this material) [18,19] , they involved fewer logistic concerns than the use of animal models          [18,19] . They are simple, easy to set up, and likely have a practically
                              indefinite shelf life. The price was reported in some studies, purporting its economic value, but the cost of the 3D printer was not considered                [17,19,23,26] .



                              The feasibility of incorporation into a training course was the focus when selecting clinically relevant steps to emulate. Therefore, most of the 3D printed
                              models focused on simulating tumor resection and renorrhaphy. Some models include other anatomical structures, potentially increasing their realism and

                              educational value  [19,26,29] .


                              The exponential increase in computing power over the last decade makes VR/AR TMs very promising. By including different teaching tasks, patient-specific

                              TMs allow preoperative rehearsal. However, signal processing delays induce a lack of realistic tissue responsiveness during the dissection of tissue planes, tissue
                              excision, suturing, knot tying, and bleeding, which significantly compromises the capacity of VR simulation to accurately emulate the PN procedure and thus
                              their value as a training tool [27,28] .
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