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 Table 3. Table of AI applications in capsule endoscopy for vascular lesions and angiodysplasias

 Year of   Study   Study                               AI
 Ref.  Application  Aim and goals  Training/Validation dataset  Results
 publication  design  location                         type
 Gan   Vascular lesions and   2008  Retrospective China  Develop computer-aided screening and   Dataset of 236 patients with lesion,   IPS  Median sensitivity of 74.2%
 [44]
 et al.  angiodysplasias  diagnosis for enteric lesions in CE  and 86 without lesion for training and
                      validation
 Leenhardt  Vascular lesions and   2018  Retrospective France  Utilise CNN for detection of AGD in SB-CE   Training: 300 normal frames,   CNN  Sensitivity of 100%, specificity
 [54]
 et al.  angiodysplasias  images  300 AGD frames               of 96%
                      Testing: 300 normal frames,
                      300 AGD frames

 Arieira   Vascular lesions and   2019  Retrospective Portugal  Evaluate accuracy and efficacy of “TOP 100”   Testing: 97 patients  TOP   No sensitivity or specificity.
 [45]
 et al.  angiodysplasias  feature                      100     Accuracy of 83.5% for P2
                                                               lesions,
                                                               95.5% for AGD, 56.7% for
                                                               ulcers,
                                                               100% for active bleeding sites
 Vieira   Vascular lesions and   2019  Retrospective Portugal  Automatic detection of AGD in WCE videos  Dataset: 27 images from KID   MLP   MLP: sensitivity of 96.60%,
 [46]                        [110]
 et al.  angiodysplasias  database  ,                  and     specificity of 94.08%
                      additional 248 AGD images,       SVM     SVM: sensitivity of 96.58%,
                      550 normal images                        specificity of 92.24%
 Vezakis   Vascular lesions and   2019  Retrospective Greece  Combining of low-level image analysis, feature  Training: 350 normal images,   CNN  Sensitivity of 92.7%, specificity
 [47]
 et al.  angiodysplasias  detection, and machine learning for AGD   196 bubble images,   of 99.5%
 detection in WCE images  75 blood vessel images,
                      104 AGD images
                      Testing: 3 full-length WCE
 Leenhardt  Vascular lesions and   2019  Retrospective France  Develop CNN methodology to detect GIA in   Training: 300 normal frames,   CNN  Sensitivity of 100%, specificity
 [48]
 et al.  angiodysplasias  SB-CE  300 GIA frames GIA            of 96%
                      Testing: 300 normal frames,
                      300 GIA frames
 Tsuboi   Vascular lesions and   2020  Retrospective Japan  Development of CNN system based on SSMB   Training: 2,237 angiodysplasia images  CNN  Sensitivity of 98.8%, specificity
 [49]
 et al.  angiodysplasias  for small bowel AGD detection  Testing: 488 AGD images,   of 98.4%
                      10,000 normal images
 Aoki   Vascular lesions and   2021  Retrospective Japan  Construct CNN based system for various   Training: 44,684 images of   CNN  No sensitivity or specificity
 [50]
 et al.  angiodysplasias  abnormality detection  abnormalities and 21,344 normal   reported. Accuracy of 100% for
                      images                                   mucosal breaks,
                      Testing: 379 full small-bowel CE         97% for AGD, 99% for
                      videos                                   protruding lesions,
                                                               and 100% for blood content
 Hwang   Vascular lesions and   2021  Retrospective Korea  Develop CNN algorithm for categorisation of   Training: 11,776 haemorrhagic lesions,  CNN  Sensitivity of 97.61%,
 [51]
 et al.  angiodysplasias  SBCE videos into haemorrhagic lesions and   18,448 ulcerative lesions,   specificity of 96.04%
 ulcerative lesions   30,224 normal images
                      Testing: 5,760 images
 Hosoe   Vascular lesions and   2022  Retrospective Japan  Detect common findings on SBCE images using  Training: 33 SBCE cases   CNN  Sensitivity of 93.4%, specificity
 [52]
 et al.  angiodysplasias  CNN framework with aim to reduce false-  Testing: 35 SBCE cases  of 97.8%
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