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Page 16 of 21                         Zhou et al. J Mater Inf 2022;2:18  https://dx.doi.org/10.20517/jmi.2022.27

               solution strengthening, precipitation hardening and TWIP/TRIP. The main obstacles to designing
               multiphase HEAs and obtaining optimal AM parameters lie in tedious experiments. ML would be an
               effective way to solve this critical problem by simplifying the relationship between the descriptor and
               targeted properties without considering the complex physical metallurgy process. However, there still exist
               some critical issues that need to be solved in the future:


               Although as-printed multiphase HEAs show excellent properties at room temperature, their mechanical
               properties at elevated temperatures are rarely reported. Like Ni-based superalloys, HEAs undergo an
               embrittling  behavior  at  intermediate  temperatures  of  ~650-900  °C,  which  is  known  as
               intermediate-temperature embrittlement [123-125] . This kind of behavior may also exist in as-printed HEAs and
               how to solve this key problem should be one of the focuses of future research.


               Microstructure and phase stability at elevated temperatures essentially determine the working temperature
               range and engineering reliability of as-printed HEAs. High-density dislocation networks are thought as one
               of the main reasons for the enhanced properties of the as-printed sample at room temperature. How these
               microstructures evolve at elevated temperatures is a matter of concern. More importantly, these dislocation
               structures may significantly influence the resistance against high-temperature creep and oxidation, which
                                       [97,126]
               also deserves detailed studies  .

               ML is expected to provide an effective method to screen alloys with desired properties and obtain optimal
               AM parameters without tedious experiments. However, there are many possible ML algorithms and
                                                                                [112]
               material descriptors, resulting in numerous possibilities for predictive results . Thus, a reasonable method
               is needed to rapidly select the best combination of the descriptors and ML algorithms. In contrast, many
               ML algorithms, especially those involving deep learning, lack interpretability and are often considered as
                         [127]
               black boxes . Sometimes, understanding the reasons behind the decision is more important than the
               decision that has been made. Therefore, efforts should be made regarding the interpretability of ML models
               to improve their efficiency and accuracy.

               DECLARATIONS
               Acknowledgements
               The authors acknowledge members from Yang’s Group for discussions towards the preparation of this
               work.


               Authors’ contributions
               Proposed the review and wrote the manuscript: Zhou Y
               Collated, analyzed, and organized the literature: Zhang Z, Wang D, Xiao W
               Discussion of some key points in this review paper: Zhou Y, Ju J, Liu S, Xiao B
               Provided supervision, acquired funding, and provided stylistic/grammatical revision on the manuscript:
               Yan M, Yang T

               Availability of data and materials
               Not applicable.


               Financial support and sponsorship
               This  research  is  supported  by  the  Shenzhen  Science  and  Technology  Program  (Grant  No.
               SGDX20210823104002016), the National Natural Science Foundation of China (No. 52101151), the Hong
               Kong Research Grant Council (RGC) (Grant No. CityU 21205621), the Shenzhen Science and Technology
               Innovation Commission (JCYJ20180504165824643).
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