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J Cancer Metastasis Treat 2019;5:31 I http://dx.doi.org/10.20517/2394-4722.2019.21 Page 32 of 36

Case presentation: We present the case of a 41-year old woman, diagnosed with breast cancer during
pregnancy, in 20th week of gestation; the cancer was found due to presence of multiple pathological
fractures of the spinal cord.

Discussion: Despite the fact that treating breast cancer during pregnancy is done following the same
principals as the management of breast cancer in non-pregnant patientstakingintoaccountthat the aim of
the treatment is to provide the best curative treatment with minimal or no harm to the fetus maximizing
the gestational period and ensure safe delivery of the fetus, is not always easy to keep the pregnancy.

Conclusion: In conclusion, with the increasing birth age for women, PABC will be a more common disease.
We have to focus our thinking on it. Elective termination of pregnancy has not proven to improve the
outcome in breast cancer. Therefore, it is not routinely recommended. The decision to terminate has to be
individualized based on the oncologic situation and maternal concerns.

Biography
Vasileva PP has completed her graduation from Medical University-Pleven, Bulgaria in 2011. Since 2012 he
has been working in Clinic of Obstetrics and gynecology, University Hospital “Dr.Georgi Stranski”-Pleven,
Bulgaria. She has several publications in various magazines on different topics. She has published more
than 10 papers in reputed journals.

42. Mild exercise training partially prevents muscle wasting induced by tumor and chemotherapy

1,2
1,2
1,2
Riccardo Ballarò , Marc Beltrà , Fabrizio Pin , Kia Ranjbar , Paola Costelli , Fabio Penna 1,2
3
1,2
1 Department of Clinical and Biological Sciences, Experimental Medicine and Clinical Pathology Unit,
University of Turin, Turin 10126, Italy.
2 Interuniversity Institute of Myology, Milano 20132, Italy.
3 Tarbiat Modares University, Tarbiat Tehran 14117, Iran.

Cachexia is a frequent feature in cancer patients. Its occurrence is associated with reduced tolerance to anti-
cancer treatments, impaired survival and bad quality of life. This syndrome is mainly characterized by loss
[1]
of body weight, depletion of muscle mass and metabolic alterations . The loss of muscle mass and function
[1]
is also associated with autophagy deregulation and mitochondrial impairments that could be exacerbated
[2]
by anti-cancer treatments . In this regard, exercise could represent a promising non-pharmacological
[3]
approach to correct muscle wasting in cancer cachexia .The main goal of the present study was to
investigate if mild exercise could improve muscle wasting in mice bearing the C26 tumor, in the presence
or in the absence of chemotherapy treatment [oxaliplatin+5-fluorouracil (OXFU)]. Although chemotherapy
increased the lifespan of C26-bearing mice, it resulted in muscle wasting more severe than that observed in
the untreated C26 hosts. Such wasting pattern was associated with increased levels of molecules accepted
as markers of autophagy and mitophagy, while the expression of markers of mitochondrial content and
dynamics decreased. Consistently, C26 OXFU mice showed impaired muscle oxidative metabolism (SDH
total activity) and reduced protein synthesis. Moderate exercise in OXFU-treated C26-bearing mice
exerted beneficial effects on the loss of both muscle mass and function, partially restoring the expression
of markers of autophagy and mitophagy, increasing mitochondrial content and dynamics and improving
muscle oxidative capacity.