Page 441 - Read Online

Page 29 of 36 J Cancer Metastasis Treat 2019;5:31 I http://dx.doi.org/10.20517/2394-4722.2019.21

Thiamine (300 nmol/L) with bortezomib antagonized the antitumor effect of bortezomib on myeloma cells.
In every cell, bortezomib was apoptotic, which effect was decreased in melanoma by the co-treatments.

A good correlation between the apoptotic and the cell cycle arresting effect of bortezomib as well as the
antagonism of the antioxidants was found. In conclusion, the combination therapy of bortezomib and a low
dose of antioxidants could be offered for the treatment of BIPN in multiple myeloma.

Biography
Angéla Takács received the Doctor of Pharmacy degree from the Semmelweis University in 2017.
Currently, she is a PhD student in the Modern Trends in Pharmaceutical Scientific Research Program at the
Department of Genetics Cell- and Immunobiology, Semmelweis University. She is woking on projects in
connection with targeted tumor therapy.

37. Profiling of the transcripts and microRNA in ovarian cancer cells subjected to fasting or to
the caloric restriction mimetic Resveratrol

2
3
1
1
1
Letizia Vallino , Alessandra Ferraresi , Chiara Vidoni , Giovanna Chiorino , Alessandra Galetto , Ciro
Isidoro 1
1 Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale “A.
Avogadro”, Novara 28100, Italy.
2 Cancer Genomics Laboratory, Fondazione Edo ed Elvo Tempia, Biella 13900, Italy.
3 Oncology Unit, Department of Translational Medicine, Università del Piemonte Orientale “A. Avogadro”,
Novara 28100, Italy.

The lack of nutrients and of growth factors has a great impact on the metabolic pathways involved in cancer
cell proliferation. In this condition, cancer cells activate autophagy as a pro-survival pathway and eventually
exit the cell cycle to undergo a dormant state. Presently, the potential benefit of nutrient starvation in the
prevention and treatment of cancer is under clinical consideration. Resveratrol (RV), a dietary polyphenol
acting as a protein (caloric) restriction mimetic, could substitute for amino acid starvation. Here we report
on the changes of the global transcriptome in ovarian cancer cells subjected to amino acid starvation or to
the protein-caloric restriction mimetic RV. Based on the Gene Ontology analysis, the mRNAs expressed in
the two treatments affected different biological functions. The number of transcripts positively impinging
on the autophagy pathway was higher in RV-treated than in starved cancer cells. Our data support the
view that RV treatment can be more effective than and can substitute for nutrient starvation to induce a
dormant-like state in cancer cells.

38. Resveratrol abrogates IL-6 - induced ovarian cancer cell motility by limiting glucose

availability and up-regulating autophagy

2
1
1
1
1
Chiara Vidoni , Alessandra Ferraresi , Suratchanee Phadngam , Andrea Castiglioni , Alessandra Galetto ,
Ciro Isidoro 1
1 Laboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Università del
Piemonte Orientale “A. Avogadro”, Novara 28100, Italy.