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Page 31 of 36 J Cancer Metastasis Treat 2019;5:31 I http://dx.doi.org/10.20517/2394-4722.2019.21

the size was 2-4 cm and in 57% the size of the local tumor is above 4 cm. Never the less the high percentage
of locally advanced process (patients with tumor above 4 cm), only in one case there was local spreading
of the tumor to the uterine cavity and in one case there lymph node metastasis. Lymphovascular space
invasion was not seen in any patient. Our patients are free of tumor recurrence or occurrence of symptoms
for a period of 9.4 years (112 months), to 4 months after the surgical procedure.

Conclusion: Warty carcinoma of the cervix has good clinical prognosis and it is possible to rethink for not
so aggressive surgical treatment and even for fertility sparing surgery when it is necessary.

40. Peptide based targeted drug delivery of mono- and dual-drug conjugates to prostate cancer
cells

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1
1
1
1,2
Michael Firer , Oranit Bashari , Boris Redko , Anna Cohen , Galia Luboshits , Gary Gellerman 2,3
1 Department of Chemical Engineering, Ariel University, Ariel 40700, Israel.
2 Ariel Center for Applied Cancer Research, Ariel University, Ariel 40700, Israel.
3 Department of Chemical Sciences, Ariel University, Ariel 40700, Israel.
Targeted drug delivery (TDD) systems are becoming important in cancer therapy for the specific delivery
of cytotoxic drugs into the target cells. This strategy bypasses the disadvantages of traditional chemotherapy
such as non-specific toxicity and development of drug resistance and may also reduce drug doses. TDD
systems commonly consist of a targeting moiety (such as an antibody, protein or peptide) chemically
conjugated to a linker which has been coupled to a cytotoxic compound. In order for targeted nanoparticles
to be effective therapeutics, a number of design issues need to be considered. This presentation will discuss
selection of appropriate peptides derived from phage display libraries as targeting moieties, focusing on
our results in the development of peptide-drug-conjugates (PDCs) for prostate cancer therapy. Based on
our previous studies in TDD systems, we defined a series of phage selection criteria which enabled the
choice of candidate peptides for testing in vitro and in vivo. Using the selection criteria, two lead peptides,
P10 and P12 were used to build mono- and dual-drug PDCs which were shown to be target specific and
effective against a variety of prostate cancer cells. These results demonstrate several important principles in
the tailored design and selection of both the peptides and cytotoxic drugs suitable for incorporation into
effective PDCs. We are now using these principles to design PDCs for other cancers.

41. Pregnancy-associated breast cancer is it always possible to keep the pregnancy

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3
2
1
2
Polina Vasileva , Angel Yordanov , Vasil Nanev , Strahil Strashilov , Ilko Iliev , Elitsa Gyokova , Yoana
1
Ivanova-Yoncheva 1
1 Department of Obstetrics and Gynecology, Medical University-Pleven, Pleven 5803, Bulgaria.
2 Department of Gynecologic Oncology, Medical University-Pleven, Pleven 5803, Bulgaria.
3 Department of Surgical Oncology, Medical University-Pleven, Pleven 5803, Bulgaria.
4 Department of Surgical Diseases, Medical University-Pleven, Pleven 5803, Bulgaria.
Introduction: Pregnancy-associated breast cancer can occur in any moment during gestation, lactation,
or even within 1 year after delivery. The incidence of that cancer is 1:3000 to 1:10000 pregnancies. The
diagnosing process is often hard due to the pregnancy-related physiological changes of the breast.