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J Cancer Metastasis Treat 2019;5:31 I http://dx.doi.org/10.20517/2394-4722.2019.21 Page 36 of 36

47. Spinless metal isotopes are able to suppress DNA Polymerase Beta in WERI/Y79 retinoblastoma
cells: beyond the cytostatic effect

Kirill V. Ermakov, Alexander A. Bukhvostov, Anton S. Dvornikov, Dmitry A. Kuznetsov

Department of Medicinal NanoBioTechnologies, School of Medicine, N. I. Pirogov Russian National Research
Medical University, Moscow 117997, Russian Federation.

Nuclear spin possessing isotopes (25Mg, 43Ca, 67Zn) promote the marked magnetic isotope effects (MIE)
on DNA Polymerase Beta (DNApolB) in ex vivo survived human retinoblastoma (RB) cells. In N-ethyl-
melamide chase experiment, the RB in situ catalytic activity of DNApolB has been selectively estimat as a
function of MIE. A resulted enzyme function breakdown leads to a sharp decrease of cancer cell viability.
This study a paramagnetic chemotherapy path is all about.