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Hadadi et al. J Cancer Metastasis Treat 2018;4:25 I http://dx.doi.org/10.20517/2394-4722.2018.22 Page 11 of 15

A

Cell viability (%)

Water extract (mg/mL)

B

Cell viability (%)

Methanol extract (mg/mL)
C

Cell viability (%)

Ethanol extract (mg/mL)
Figure 8. Effect of papaya extracts on AU565 breast cancer cells. The effect of water (A), methanol (B), or ethanol (C) extracts on
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viability of AU565 (ER /Her-2 ) breast cancer cells was measured as described in the “METHODS”. All significant differences between
control and treated cells are indicated by “*” and are reported at P < 0.05
lines (MDA-MB-231 & SK-Br-3) irrespective to their Her-2 receptors expression whereas papaya extract from
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seeds and leaves were not effective on ER cell lines (MCF-7 & AU565). To further validate the effects on ER
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breast cancer cells, we used another ER breast cancer cell lines, AU565 cell line (ER/Her-2 ).
The effect of water extract from leaves and seeds is shown in Figure 8A. The extract from seeds has no
significant effect; however, leaves extract reduced cell viability starting at 50 mg/mL. The cell viability