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Page 8 of 15                           Hadadi et al. J Cancer Metastasis Treat 2018;4:25  I  http://dx.doi.org/10.20517/2394-4722.2018.22

                                  A




                                      Cell viability (%)













                                                       Water extract (mg/mL)

                                  B




                                      Cell viability (%)













                                                       Methanol extract (mg/mL)
                                  C





                                      Cell viability (%)













                                                       Ethanol extract (mg/mL)
               Figure 5. Effect of papaya extracts on MCF-7 breast cancer cells. The effect of water (A), methanol (B), or ethanol (C) extracts on viability
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                             -
               of MCF-7 (ER /Her-2 ) breast cancer cells was measured as described in the “METHODS”. All significant differences between control and
               treated cells are indicated by “*” and are reported at P < 0.05
               Effect of papaya leaves and seeds extract on MDA-MB-361 breast cancer cells
               The effect of papaya extract on ER /Her-2  breast cancer cell lines were investigated using MDA-MB-361 cell
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               lines. We again tested only extracts from leaves and seeds as explained earlier. The effect of water extract
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