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Hadadi et al. J Cancer Metastasis Treat 2018;4:25  I  http://dx.doi.org/10.20517/2394-4722.2018.22                          Page 9 of 15

                                   A




                                      Cell viability (%)













                                                        Water extract (mg/mL)
                                   B




                                      Cell viability (%)












                                                        Methanol extract (mg/mL)

                                   C





                                      Cell viability (%)












                                                        Ethanol extract (mg/mL)
               Figure 6. Effect of papaya extracts on SK-Br-3 breast cancer cells. The effect of water (A), methanol (B), or ethanol (C) extracts on
                               -
                                    +
               viability of SK-Br-3 (ER /Her-2 ) breast cancer cells was measured described in the “METHODS”. All significant differences between
               control and treated cells are indicated by “*” and are reported at P < 0.05
               from leaves and seeds is shown in Figure 7A. The extract from seeds and leaves have no significant effect on
               cell viability of MDA-MB-361 breast cancer cells.


               The effect of methanol extract from leaves and seeds is shown in Figure 7B. The data indicate that none of
               the papaya fractions has any significant effect on cell viability of MDA-MB-361 breast cancer cells.
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