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Page 10 of 15 Hadadi et al. J Cancer Metastasis Treat 2018;4:25 I http://dx.doi.org/10.20517/2394-4722.2018.22

A

Cell viability (%)

Water extract (mg/mL)

B

Cell viability (%)

Methanol extract (mg/mL)

C

Cell viability (%)

Ethanol extract (mg/mL)

Figure 7. Effect of papaya extracts on MDA-MB-361 breast cancer cells. The effect of water (A), methanol (B), or ethanol (C) extracts
+
+
on viability of MDA-MB-361 (ER /Her-2 ) breast cancer cells was measured as described in the “METHODS”. All significant differences
between control and treated cells are indicated by “*” and are reported at P < 0.05
The effect of ethanol extract from leaves and seeds is shown in Figure 7C. The data indicate that none of the
papaya fractions also has any significant effect on cell viability of MDA-MB-361 breast cancer cells.

Effect of papaya leaves and seeds extract on AU565 breast cancer cells
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From data shown above, we found that papaya extract from leaves and seeds were effective against ER cell