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Hadadi et al. J Cancer Metastasis Treat 2018;4:25 I http://dx.doi.org/10.20517/2394-4722.2018.22 Page 7 of 15

A

Cell viability (%)

Water extract (mg/mL)
B

Cell viability (%)

Methanol extract (mg/mL)

C

Cell viability (%)

Ethanol extract (mg/mL)

Figure 4. Effect of papaya extracts on MDA-MB-231 breast cancer cells. The effect of water (A), methanol (B), or ethanol (C) extracts
on viability of MDA-MB-231 (ER /Her-2 ) breast cancer cells was measured as described in the “METHODS”. Data is calculated as %
-
-
inhibition of cell growth. All significant differences between control and treated cells are indicated by “*” and are reported at P < 0.05
The effect of methanol extract from leaves and seeds is shown in Figure 6B. The data indicate that none of
the papaya fractions has any significant effect on cell viability of SK-Br-3 breast cancer cells.

The effect of ethanol extract from leaves and seeds is shown in Figure 6C. Similar to methanol extracts, the
data indicate that none of the ethanol extract from papaya leaves or seeds has any significant effect on cell
viability of SK-Br-3 breast cancer cells.