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-9 and -3 activations, DNA fragmentation, and the inhibition Science Council of Taiwan (NSC99-2314-B-038-032,
of both CXCR4/CXCL12 and STAT3/IL-6 pathways. To NSC100-2314-B-038-016 to SK Liao) and Chang Gung
our knowledge, WA inhibition of IFN-γ-induced mCSCs via Medical Research Fund (CMRPD170043, CMRPG3A0811
CXCR4/CXCL12 axis is reported herein for the first time. In to ST Pang and SK Liao).
addition, WA exerts the anti-angiogenic effect by targeting
and binding vimentin, and WA cytotoxicity requires early Conflicts of interest
ROS production and GSH depletion, and the inhibition of
ROS increase resulting in complete suppression of a series There are no conflicts of interest.
of cellular events. Collectively, these results strongly
[18]
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This study was supported by grants from the National upregulation of tumor suppressor proteins in human cervical cancer

Journal of Cancer Metastasis and Treatment ¦ Volume 2 ¦ Issue 1 ¦ January 15, 2016 ¦ 39