Page 286 - Read Online
P. 286
vivo. Cancer Res 2007;67:11141-6. Downregulation of CYP2E1 ameliorates oxidative stress and
24. Miller TW, Isenberg JS, Roberts DD. Molecular regulation of apoptosis. Heart 2011;97:A69.
tumor angiogenesis and perfusion via redox signaling. Chem Rev 43. Jin M, Ande A, Kumar A, Kumar S. Regulation of cytochrome P450
2009;109:3099-124. 2e1 expression by ethanol: role of oxidative stress-mediated pkc/
25. Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: jnk/sp1 pathway. Cell Death Dis 2013;4:e554.
physiology and pathology. Trends Biochem Sci 2011;36:30-8. 44. Lewis MD, Roberts BJ. Role of CYP2E1 activity in endoplasmic
26. Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia reticulum ubiquitination, proteasome association, and the unfolded
M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, protein response. Arch Biochem Biophys 2005;436:237-45.
Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, 45. Nebert DW, Dalton TP. The role of cytochrome P450 enzymes in
Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow endogenous signalling pathways and environmental carcinogenesis.
AR, Rubinsztein DC. Regulation of mammalian autophagy in Nat Rev Cancer 2006;6:947-60.
physiology and pathophysiology. Physiol Rev 2010;90:1383-435. 46. Zangar RC, Davydov DR, Verma S. Mechanisms that regulate
27. Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: production of reactive oxygen species by cytochrome P450. Toxicol
disease relevance and therapeutic opportunities. Nat Rev Drug Appl Pharmacol 2004;199:316-31.
Discov 2008;7:1013-30. 47. Namazi MR. Cytochrome-P450 enzymes and autoimmunity:
28. Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. expansion of the relationship and introduction of free radicals as the
Trends Cell Biol 2004;14:20-8. link. J Autoimmune Dis 2009;6:4.
29. Leung T, Rajendran R, Singh S, Garva R, Krstic-Demonacos M, 48. Nizamutdinova IT, Lee GW, Son KH, Jeon SJ, Kang SS, Kim YS,
Demonacos C. Cytochrome P450 2E1 (CYP2E1) regulates the Lee JH, Seo HG, Chang KC, Kim HJ. Tanshinone I effectively
response to oxidative stress and migration of breast cancer cells. induces apoptosis in estrogen receptor-positive (MCF-7) and
Breast Cancer Res 2013;15:R107. estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int
30. Pavlova NN, Thompson CB. The emerging hallmarks of cancer J Oncol 2008;33:485-91.
metabolism. Cell Metab 2016;23:27-47. 49. Kim DK, Kim YH, Jang HH, Park J, Kim JR, Koh M, Jeong WI,
31. Liemburg-Apers DC, Willems PH, Koopman WJ, Grefte S. Koo SH, Park TS, Yun CH, Park SB, Chiang JY, Lee CH, Choi HS.
Interactions between mitochondrial reactive oxygen species and Estrogen-related receptor gamma controls hepatic CB1 receptor-
cellular glucose metabolism. Arch Toxicol 2015;89:1209-26. mediated CYP2E1 expression and oxidative liver injury by alcohol.
32. Kang SW, Lee S, Lee EK. ROS and energy metabolism in cancer Gut 2013;62:1044-54.
cells: alliance for fast growth. Arch Pharm Res 2015;38:338-45. 50. Aitken AE, Richardson TA, Morgan ET. Regulation of drug-
33. El Sayed SM, Mahmoud AA, El Sawy SA, Abdelaal EA, Fouad metabolizing enzymes and transporters in inflammation. Annu Rev
AM, Yousif RS, Hashim MS, Hemdan SB, Kadry ZM, Abdelmoaty Pharmacol Toxicol 2006;46:123-49.
MA, Gabr AG, Omran FM, Nabo MM, Ahmed NS. Warburg 51. Das J, Ghosh J, Manna P, Sil PC. Taurine protects acetaminophen-
effect increases steady-state ROS condition in cancer cells induced oxidative damage in mice kidney through APAP urinary
through decreasing their antioxidant capacities (anticancer effects excretion and CYP2E1 inactivation. Toxicology 2010;269:24-34.
of 3-bromopyruvate through antagonizing Warburg effect). Med 52. Das J, Ghosh J, Manna P, Sil PC. Acetaminophen induced acute
Hypotheses 2013;81:866-70. liver failure via oxidative stress and JNK activation: protective role
34. Vaclavikova R, Hubackova M, Stribrna-Sarmanova J, Kodet R, of taurine by the suppression of cytochrome P450 2E1. Free Radic
Mrhalova M, Novotny JAN, Gut I, Soucek P. RNA expression Res 2010;44:340-55.
of cytochrome P450 in breast cancer patients. Anticancer Res 53. Cederbaum A. Nrf2 and antioxidant defense against CYP2E1
2007;27:4443-50. toxicity. Expert Opin Drug Metab Toxicol 2009;5:1223-44.
35. Zheng J. Energy metabolism of cancer: Glycolysis versus oxidative 54. Shutt DC, O’Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-
phosphorylation (Review). Oncol Lett 2012;4:1151-7. D-glucose induces oxidative stress and cell killing in human
36. Hu Y, Mishin V, Johansson I, von Bahr C, Cross A, Ronis MJ, neuroblastoma cells. Cancer Biol Ther 2010;9:853-61.
Badger TM, Ingelman-Sundberg M. Chlormethiazole as an 55. Ihrlund LS, Hernlund E, Khan O, Shoshan MC. 3-Bromopyruvate
efficient inhibitor of cytochrome P450 2E1 expression in rat liver. J as inhibitor of tumour cell energy metabolism and chemopotentiator
Pharmacol Exp Ther 1994;269:1286-91. of platinum drugs. Mol Oncol 2008;2:94-101.
37. Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen 56. Wickramasekera NT, Das GM. Tumor suppressor p53 and estrogen
J, Raunio H. Inhibition and induction of human cytochrome P450 receptors in nuclear-mitochondrial communication. Mitochondrion
enzymes: current status. Arch Toxicol 2008;82:667-715. 2014;16:26-37.
38. Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive 57. Rodriguez-Enriquez S, Carreno-Fuentes L, Gallardo-Perez JC,
oxygen species (ROS) and ROS-induced ROS release. Physiol Rev Saavedra E, Quezada H, Vega A, Marin-Hernandez A, Olin-
2014;94:909-50. Sandoval V, Torres-Marquez ME, Moreno-Sanchez R. Oxidative
39. Kroemer G, Galluzzi L, Brenner C. Mitochondrial Membrane phosphorylation is impaired by prolonged hypoxia in breast
Permeabilization in Cell Death. Physiol Rev 2007;87:99-163. and possibly in cervix carcinoma. Int J Biochem Cell Biol
40. Schattenberg JM, Czaja MJ. Regulation of the effects of CYP2E1- 2010;42:1744-51.
induced oxidative stress by JNK signaling. Redox biology 2014;3:7-15. 58. Doherty JR, Cleveland JL. Targeting lactate metabolism for cancer
41. Raza H, Prabu SK, Robin MA, Avadhani NG. Elevated therapeutics. J Clin Invest 2013;123:3685-92.
mitochondrial cytochrome P450 2E1 and glutathione S-transferase 59. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart
A4-4 in streptozotocin-induced diabetic rats: tissue-specific JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham
variations and roles in oxidative stress. Diabetes 2004;53:185-94. JC, Brand MD. Superoxide activates mitochondrial uncoupling
42. Lvdan, Wei Z, Baodan, Xiongzhi F, Huang L, Lianfeng Z. proteins. Nature 2002;415:96-9.
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Journal of Cancer Metastasis and Treatment ¦ Volume 2 ¦ July 29, 2016 ¦