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Editorial


            Introduction to Volume 1 Issue 2 of Journal of Cancer Metastasis and
            Treatment

            Lucio Miele
            Stanley Scott Cancer Center, Louisiana State Health Sciences Center and Louisiana Cancer Research Consortium, New Orleans, LA 70112, USA.
            Correspondence to: Prof. Lucio Miele, Stanley Scott Cancer Center, Louisiana State Health Sciences Center and Louisiana Cancer Research
            Consortium, New Orleans, LA 70112, USA. E-mail: lmiele@lsuhsc.edu

            It is my privilege to introduce the second issue of the   for the management of squamous non-small cell lung
            Journal of Cancer Metastasis and Treatment. In keeping   cancer (NSCLC); and the pharmacological properties
            with the format we have chosen for our journal, this   of Withania somnifera extract in a triple-negative breast
            issue contains two reviews focusing on  fi elds of great   cancer model. miRNAs and other non-coding RNAs in
            translational and clinical interest,  fi ve original articles,   biological  fl uids promise to revolutionize the world of
            and three case reports.  The  fi rst review discusses the   biomarkers. However, there remain signifi cant  technical
            rapidly evolving  fi eld of circulating tumor cells (CTC)   issues surrounding the reproducible quantifi cation  of
            as cancer biomarkers. Since the introduction of the fi rst   miRNAs for clinical purposes.  The manuscript by
            Food and Drug  Administration approved CTC test to   Shalaby  et al. is an example of progress in this highly
            assess the progression of metastatic breast, colorectal   promising  fi eld.  The manuscript by Zeeneldin  et al.
            and prostate cancer, CTC have generated tremendous   describes the experience of treating diffuse large B-cell
            interest among clinicians seeking sensitive progression   NHL in a geriatric setting where safety and effi cacy
            biomarkers and basic scientists interested in isolating   considerations have be balanced against each other and
            and studying these cells.  A number of new sorting,   where monoclonal antibodies are not always available.
            capture, and enumeration technologies are being   The study by Chivukula  et al. proposes the intriguing
            evaluated. Competing technologies have emerged, such   hypothesis that immunohistochemical detection of
            as circulating tumor DNA.  The review by Potdar and   the transcription factor GATA3 and “pioneer” factor
            Lotey summarizes the current experience with CTC as   FOXA1 has prognostic value in breast cancer.  The
            diagnostic and prognostic biomarkers and the future of   manuscript by Savini  et al. describes the experience
            this technology. The review by Alfonso  et al. describes   of this group treating squamous NSCLC, analyzing
            recent progress in our understanding of urothelial   variables associated with improved survival in their
            cancer, a poorly understood malignancy that can be very   patient population.  The article by Ray  et al. describes
            diffi cult to treat, based on novel translational science.   the effect of a promising natural product, an extract from
            The original articles cover a variety of translational and   well-known medicinal plant  Withania somnifera, on the
            clinical topics: the rapidly growing fi eld of extracellular   production of cytokines associated with metastasis in
            microRNA (miRNA) detection and quantifi cation,  as   a standard triple-negative breast cancer model. Finally,
            applied to medulloblastoma; the management of diffuse   the three case reports describe unusual presentations,
            large B-cell non-Hodgkin lymphoma (NHL) in elderly   including histologically different metastases from an
            Egyptian patients; the prognostic value of GATA3 and   unknown primary lesion, orbital metastasis from rectal
            FOXA1 detection in breast cancer; current clinical criteria   carcinoma and a mature spinal teratoma presenting in an
                                                              elderly patient.
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                                                              I hope you enjoy reading this issue, and the ones that
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                                 Website:
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                                                               How to cite this article: Miele L, Introduction to Volume 1 Issue 2
                                                               of Journal of Cancer Metastasis and Treatment. J Cancer Metastasis
                                                               Treat 2015;1:43.
                                 DOI:
                                 10.4103/2394-4722.160150      Received: 11-06-2015; Accepted: 18-06-2015.
                                                               Source of Support: Nil, Confl ict of Interest: None declared.












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