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and second lumbar vertebral body, and suggestive of
metastatic disease. Therefore, the patient was diagnosed
with rectal carcinoma with multiple distant metastases.
Palliative radiotherapy to the left orbit, lumbar spine, and
right hemipelvis was given. The patient agreed to publish
her pictures and signed the consent form.
Discussion
Rectal carcinoma in the young is increasing in incidence.
This may be associated with familial adenomatous
polyposis and hereditary non-polyposis colorectal
Figure 1: 5 cm × 3 cm × 4 cm swelling over left temporal region
cancer (Lynch) syndrome. Metastatic tumors to the
orbit are rare and most commonly are from lung, breast,
prostate, and kidney primaries. Only 5% are from the
gastrointestinal tract. [3,4] A review of the literature revealed
only 6 cases reported of primary colorectal malignancy
metastasizing to the orbit, with only three showing
histopathology. When gastrointestinal cancers metastasize
[5]
to the orbit, this is usually combined with multiple
disseminated metastases. Management of metastatic
[6]
orbital tumors requires a multidisciplinary team approach
including radiotherapy, chemotherapy, and surgery.
References

1. Chekrine T, Hassouni A, Hatime M, Jouhadi H,
Benchakroun N, Bouchbika Z, Tawfi q N, Sahraoui S,
Figure 2: Computed tomography scan showing a mixed density mass along
lateral wall of left retro-orbital area, adherent to optic nerve Benider A. Orbital metastasis from mucinous adenocarcinoma
of the rectum. J Fr Ophtalmol 2013;36:e73-5.
2. Ezra E, Vardy S, Rose G. Metastatic colonic adenocarcinoma
of the orbit with intraneural extension from the brow to the
brainstem. Eye (Lond) 1995;9 (Pt 3):371-2.
3. Shields JA, Shields CL, Brotman HK, Carvalho C, Perez N,
Eagle RC Jr. Cancer metastatic to the orbit: The 2000 Robert M.
Curts Lecture. Ophthal Plast Reconstr Surg 2001;17:346-54.
4. Goldberg RA, Rootman J, Cline RA. Tumors metastatic to the
orbit: a changing picture. Surv Ophthalmol 1990;35:1-24.
5. Charles NC, Ng DD, Zoumalan CI. Signet cell adenocarcinoma
of the rectum metastatic to the orbit. Ophthal Plast Reconstr
Surg 2012;28:e1-2.
6. Chen SF, Yii CY, Chou JW. Colon cancer with orbital
metastasis. Clin Gastroenterol Hepatol 2011;9:e76-7.

How to cite this article: Lachi PK, Uppin MS, Irukulla M,
Jaganadha Rao Naidu KV. Orbital metastasis from anorectal
carcinoma. J Cancer Metastasis Treat 2015;1:104-5.

Figure 3: Morphology showing papillae and acinar pattern of columnar cells Received: 13-01-2015; Accepted: 11-05-2015.
with moderate cytoplasm, oval nucleus, increased nuclear-cytoplasmic ratio Source of Support: Nil, Confl ict of Interest: None declared.

Journal of Cancer Metastasis and Treatment ¦ Volume 1 ¦ Issue 2 ¦ July 15, 2015 ¦ 105