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Jalal et al. J Cancer Metastasis Treat 2023;9:11 Journal of Cancer
DOI: 10.20517/2394-4722.2022.122
Metastasis and Treatment

Review Open Access

Recent advances in detecting premalignant
pancreatic cysts

1
2
3,4
Mustafa Jalal , Sebastine A. Gbadegesin , Sazgar Ibrahim , Nadeem Tehami 5
1
Department of Gastroenterology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK.
2
Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield S5 7AU, UK.
3
Department of Surgery, Hawler Teaching Hospital, Erbil, Iraq.
4
Department of Surgery, Hawler Medical University, P.O. BOX 178, Erbil, Iraq.
5
Department of Gastroenterology and Hepatology, Southampton General Hospital, Southampton, Tremona Road, Southampton
SO16 6YD, UK.
Correspondence to: Dr. Mustafa Jalal, Department of Gastroenterology, Royal Bournemouth Hospital, Castle Lane East,
Bournemouth BH7 7DW, UK. E-mail: mustafa.jalal@nhs.net
How to cite this article: Jalal M, Gbadegesin SA, Ibrahim S, Tehami N. Recent advances in detecting premalignant pancreatic
cysts. J Cancer Metastasis Treat 2023;9:11. https://dx.doi.org/10.20517/2394-4722.2022.122
Received: 21 Oct 2022 First Decision: 24 Feb 2023 Revised: 8 Mar 2023 Accepted: 3 Apr 2023 Published: 15 Apr 2023

Academic Editors: Antonio Facciorusso, Marco Falasca Copy Editor: Fangling Lan Production Editor: Fangling Lan

Abstract
The incidental discovery of pancreatic cysts in asymptomatic patients is on the rise due to the widespread use of
cross-sectional imaging. The challenge in the management of pancreatic cysts is in distinguishing those with
malignant potentials, like mucinous pancreatic cysts, from non-mucinous cysts that have negligible malignant
potentials. Similarly, it can be difficult to identify mucinous cysts that harbour high-grade dysplasia or early cancer.
This review focuses on the recent advances in detecting pancreatic cancer and cysts with premalignant potential.

Keywords: Pancreatic cysts, mucinous cyst neoplasm, IPMN, endoscopic ultrasound, pancreatic cancer

INTRODUCTION
Pancreatic cysts are a common discovery in clinical practice. The incidence of asymptomatic pancreatic
cysts is expected to increase due to the widespread use of cross-sectional imaging techniques such as
computed tomography (CT) and magnetic resonance imaging (MRI) scans . Pancreatic cancer is the
[1]
[2]
seventh leading cause of cancer-related death worldwide; the survival rate after five years is only 7% . Some

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0
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