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Farkas et al. J Cancer Metastasis Treat 2022;8:37 https://dx.doi.org/10.20517/2394-4722.2022.89 Page 3 of 13

Figure 1. Epithelioid mesothelioma characterized by a proliferation of tumor cells with round nuclei, ample cytoplasm, and cellular
cohesion (H&E 200×).

Figure 2. Sarcomatoid mesothelioma characterized by a haphazard proliferation of malignant spindle cells (H&E 200×).

[8]
cytologic feature observed in sarcomatoid mesothelioma . While the name and cytomorphology suggest
that these cells are transitioning or are halfway between epithelioid and sarcomatoid mesothelioma,
[18]
transitional mesotheliomas are more similar to the sarcomatoid subtype genomically . Given their
genomic relatedness to sarcomatoid mesothelioma, it is not surprising that transitional mesothelioma is also
associated with a worse prognosis, in line with what has been reported in sarcomatoid mesothelioma [18,19] .