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Page 8 of 13 Farkas et al. J Cancer Metastasis Treat 2022;8:37 https://dx.doi.org/10.20517/2394-4722.2022.89
Figure 7. Epithelioid mesothelioma showing nuclear loss of BAP1. Note small lymphocytes with retained expression (400×).
Figure 8. Epithelioid mesothelioma showing cytoplasmic loss of MTAP. Note inflammatory cells with retained expression (400×).
The emergence of these markers of malignancy in mesothelial proliferations has implications for the
cytologic diagnosis of mesothelioma. Studies do exist showing that loss of BAP1 and MTAP staining can be
observed in cytologic fluids from patients with mesothelioma. How this impacts the cytologic examination
of fluids is beyond the scope of this review, but this area of cytology is expected to change in the coming
years [50,51] .
