Page 26 - Read Online
P. 26

137. Minchinton AI, Tannock IF. Drug penetration in solid tumours.   as  a  modulator  of  cellular  redox  balance.  Cancer Res
               Nat Rev Cancer 2006;6:583-92.                      2008;68:2870-7.
            138. Hockel  M,  Vaupel  P.  Tumor  hypoxia:  defi nitions  and  current   146. Montero  AJ,  Diaz-Montero  CM,  Deutsch  YE,  Hurley  J,
               clinical,  biologic,  and  molecular  aspects.  J  Natl Cancer Inst   Koniaris LG, Rumboldt T, Yasir S, Jorda M, Garret-Mayer E,
               2001;93:266-76.                                    Avisar  E,  Slingerland  J,  Silva  O,  Welsh  C,  Schuhwerk  K,
                139. Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer   Seo  P,  Pegram  MD,  Gluck  S.  Phase  2  study  of  neoadjuvant
               treatment. Nat Rev Cancer 2004;4:437-47.           treatment  with  NOV-002  in  combination  with  doxorubicin
            140. Wilson  WR,  Hay  MP.  Targeting  hypoxia  in  cancer  therapy.   and cyclophosphamide followed by docetaxel in patients with
               Nat Rev Cancer 2011;11:393-410.                    HER-2  negative  clinical  stage  II-IIIc  breast  cancer.  Breast
                141. Brown  JM,  Lemmon  MJ.  Potentiation  by  the  hypoxic   Cancer Res Treat 2012;132:215-23.
               cytotoxin  SR  4233  of  cell  killing  produced  by  fractionated
               irradiation of mouse tumors. Cancer Res 1990;50:7745-9.    147. Ishimoto  T,  Nagano  O,  Yae  T,  Tamada  M,  Motohara  T,
            142. DiSilvestro  PA,  Ali  S,  Craighead  PS,  Lucci  JA,  Lee  YC,   Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T,
               Cohn DE, Spirtos NM, Tewari KS, Muller C, Gajewski WH,   Shimizu  T,  Ishikawa  T,  Kai  K,  Takahashi  E,  Imamura  Y,
               Steinhoff MM, Monk BJ. Phase III randomized trial of weekly   Baba  Y,  Ohmura  M,  Suematsu  M,  Baba  H,  Saya  H.  CD44
               cisplatin  and  irradiation  versus  cisplatin  and  tirapazamine   variant  regulates  redox  status  in  cancer  cells  by  stabilizing
               and irradiation in stages IB2, IIA, IIB, IIIB, and IVA cervical   the xCT subunit of system xc(-) and thereby promotes tumor
               carcinoma limited to the pelvis: a gynecologic oncology group   growth. Cancer Cell 2011;19:387-400.
               study. J Clin Oncol 2014;32:458-64.            148. Lo M, Ling V, Low C, Wang YZ, Gout PW. Potential use of
                143. Duan JX, Jiao H, Kaizerman J, Stanton T, Evans JW, Lan L,   the anti-infl ammatory drug, sulfasalazine, for targeted therapy
               Lorente G, Banica M, Jung D, Wang J, Ma H, Li X, Yang Z,   of pancreatic cancer. Curr Oncol 2010;17:9-16.
               Hoffman RM, Ammons WS, Hart CP, Matteucci M. Potent and   149. Guan J, Lo M, Dockery P, Mahon S, Karp CM, Buckley AR,
               highly  selective  hypoxia-activated  achiral  phosphoramidate   Lam  S,  Gout  PW,  Wang  YZ.  The  xc-  cystine/glutamate
               mustards as anticancer drugs. J Med Chem 2008;51:2412-20.  antiporter  as  a  potential  therapeutic  target  for  small-cell  lung
            144. Borad  MJ,  Reddy  SG,  Bahary  N,  Uronis  HE,  Sigal  D,   cancer:  use  of  sulfasalazine.  Cancer Chemother Pharmacol
               Cohn  AL,  Schelman  WR,  Stephenson  J  Jr,  Chiorean  EG,
               Rosen  PJ,  Ulrich  B,  Dragovich  T,  Del  Prete  SA,  Rarick  M,   2009;64:463-72.
               Eng  C,  Kroll  S,  Ryan  DP.  Randomized  phase  II  trial  of   150. Wang  JB,  Erickson  JW,  Fuji  R,  Ramachandran  S,  Gao  P,
               gemcitabine  plus TH-302  versus  gemcitabine  in  patients  with   Dinavahi  R,  Wilson  KF, Ambrosio AL,  Dias  SM,  Dang  CV,
               advanced pancreatic cancer. J Clin Oncol 2015;33:1475-81.  Cerione   RA.   Targeting   mitochondrial   glutaminase
                145. Townsend  DM,  He  L,  Hutchens  S,  Garrett  TE,  Pazoles  CJ,   activity  inhibits  oncogenic  transformation.  Cancer Cell
               Tew  KD.  NOV-002,  a  glutathione  disulfi de  mimetic,   2010;18:207-19.













































            182                                   Journal of Cancer Metastasis and Treatment  ¦  Volume 1 ¦ Issue 3 ¦ October 15, 2015 ¦
   21   22   23   24   25   26   27   28   29   30   31