Page 23 - Read Online

Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Bodian C, Slater G, Weiss A, Burstein DE. GLUT1 glucose
Ogino S. HIF1A overexpression is associated with poor transporter expression in colorectal carcinoma: a marker for
prognosis in a cohort of 731 colorectal cancers. Am J Pathol poor prognosis. Cancer 1998;83:34-40.
2010;176:2292-301. 58. Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I,
43. Zheng SS, Chen XH, Yin X, Zhang BH. Prognostic Morris HR, Allard WJ, Lienhard GE, Lodish HF. Sequence
signifi cance of HIF-1alpha expression in hepatocellular and structure of a human glucose transporter. Science
carcinoma: a meta-analysis. PLoS One 2013;8:e65753. 1985;229:941-5.
44. Nakamura J, Kitajima Y, Kai K, Mitsuno M, Ide T, 59. Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N. Crystal
Hashiguchi K, Hiraki M, Miyazaki K. Hypoxia-inducible structure of the human glucose transporter GLUT1. Nature
factor-1alpha expression predicts the response to 2014;510:121-5.
5-fl uorouracil-based adjuvant chemotherapy in advanced 60. Griffi ths EA, Pritchard SA, Welch IM, Price PM, West CM.
gastric cancer. Oncol Rep 2009;22:693-9. Is the hypoxia-inducible factor pathway important in gastric
45. Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, cancer? Eur J Cancer 2005;41:2792-805.
Noshiro H, Miyazaki K. HIF-1alpha is an unfavorable 61. Dang CV, Le A, Gao P. MYC-induced cancer cell energy
determinant of relapse in gastric cancer patients who metabolism and therapeutic opportunities. Clin Cancer Res
underwent curative surgery followed by adjuvant 5-FU 2009;15:6479-83.
chemotherapy. Int J Cancer 2010;127:1158-71. 62. Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P,
46. Griffi ths EA, Pritchard SA, McGrath SM, Valentine HR, Rajagopalan H, Schmidt K, Willson JK, Markowitz S,
Price PM, Welch IM, West CM. Hypoxia-associated Zhou S, Diaz LA Jr, Velculescu VE, Lengauer C, Kinzler KW,
markers in gastric carcinogenesis and HIF-2alpha in gastric Vogelstein B, Papadopoulos N. Glucose deprivation
and gastro-oesophageal cancer prognosis. Br J Cancer contributes to the development of KRAS pathway mutations
2008;98:965-73. in tumor cells. Science 2009;325:1555-9.
47. Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, 63. Kawada K, Nakamoto Y, Kawada M, Hida K, Matsumoto T,
McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Murakami T, Hasegawa S, Togashi K, Sakai Y. Relationship
Guenther T. Hypoxia-inducible factor-1alpha and -2alpha are between 18F-fl uorodeoxyglucose accumulation and
expressed in most rectal cancers but only hypoxia-inducible KRAS/BRAF mutations in colorectal cancer. Clin Cancer Res
factor-1alpha is associated with prognosis. Br J Cancer 2012;18:1696-703.
2009;100:1666-73. 64. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA,
48. Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent
Greene J, Cocito A, Amati B. Genomic targets of the human phosphorylation and nuclear translocation of PKM2 promotes
c-Myc protein. Genes Dev 2003;17:1115-29. the Warburg effect. Nat Cell Biol 2012;14:1295-304.
49. Lutz W, Leon J, Eilers M. Contributions of Myc to 65. Young CD, Lewis AS, Rudolph MC, Ruehle MD,
tumorigenesis. Biochim Biophys Acta 2002;1602:61-71. Jackman MR, Yun UJ, Ilkun O, Pereira R, Abel ED,
50. de Souza CR, Leal MF, Calcagno DQ, Costa Sozinho EK, Anderson SM. Modulation of glucose transporter 1 (GLUT1)
Borges Bdo N, Montenegro RC, Dos Santos AK, Dos expression levels alters mouse mammary tumor cell growth
Santos SE, Ribeiro HF, Assumpcao PP, de Arruda Cardoso in vitro and in vivo. PLoS One 2011;6:e23205.
Smith M, Burbano RR. MYC deregulation in gastric 66. Kwee SA, Hernandez B, Chan O, Wong L. Choline kinase
cancer and its clinicopathological implications. PLoS One alpha and hexokinase-2 protein expression in hepatocellular
2013;8:e64420. carcinoma: association with survival. PLoS One 2012;7:e46591.
51. Joost HG, Thorens B. The extended GLUT-family of 67. Paudyal B, Paudyal P, Oriuchi N, Tsushima Y, Nakajima T,
sugar/polyol transport facilitators: nomenclature, sequence Endo K. Clinical implication of glucose transport and
characteristics, and potential function of its novel metabolism evaluated by 18F-FDG PET in hepatocellular
members (review). Mol Membr Biol 2001;18:247-56. carcinoma. Int J Oncol 2008;33:1047-54.
52. Younes M, Lechago LV, Somoano JR, Mosharaf M, Lechago J. 68. Gong L, Cui Z, Chen P, Han H, Peng J, Leng X. Reduced
Immunohistochemical detection of Glut3 in human tumors and survival of patients with hepatocellular carcinoma expressing
normal tissues. Anticancer Res 1997;17:2747-50. hexokinase II. Med Oncol 2012;29:909-14.
53. Ayala FR, Rocha RM, Carvalho KC, Carvalho AL, 69. Mathupala SP, Ko YH, Pedersen PL. Hexokinase-2 bound to
da Cunha IW, Lourenco SV, Soares FA. GLUT1 and GLUT3 mitochondria: cancer’s stygian link to the “Warburg Effect”
as potential prognostic markers for Oral Squamous Cell and a pivotal target for effective therapy. Semin Cancer Biol
Carcinoma. Molecules 2010;15:2374-87. 2009;19:17-24.
54. Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, 70. David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP
Dierckx R, Van de Wiele C. Expression of hexokinases and proteins controlled by c-Myc deregulate pyruvate kinase
glucose transporters in treated and untreated oesophageal mRNA splicing in cancer. Nature 2010;463:364-8.
adenocarcinoma. Histol Histopathol 2009;24:971-7. 71. Clower CV, Chatterjee D, Wang Z, Cantley LC,
55. Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Baba Y, Vander Heiden MG, Krainer AR. The alternative splicing
Sugihara H, Izumi D, Kurashige J, Baba H. High expression repressors hnRNP A1/A2 and PTB infl uence pyruvate kinase
of glucose transporter 1 on primary lesions of esophageal isoform expression and cell metabolism. Proc Natl Acad
squamous cell carcinoma is associated with hematogenous Sci U S A 2010;107:1894-9.
recurrence. Ann Surg Oncol 2014;21:1756-62. 72. Christofk HR, Vander Heiden MG, Harris MH,
56. Kawamura T, Kusakabe T, Sugino T, Watanabe K, Fukuda T, Ramanathan A, Gerszten RE, Wei R, Fleming MD,
Nashimoto A, Honma K, Suzuki T. Expression of glucose Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate
transporter-1 in human gastric carcinoma: association with kinase is important for cancer metabolism and tumour growth.
tumor aggressiveness, metastasis, and patient survival. Cancer Nature 2008;452:230-3.
2001;92:634-41. 73. Yang W, Lu Z. Regulation and function of pyruvate kinase M2
57. Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, in cancer. Cancer Lett 2013;339:153-8.

Journal of Cancer Metastasis and Treatment ¦ Volume 1 ¦ Issue 3 ¦ October 15, 2015 ¦ 179