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Maitland                                                                                                                                                                           Prostate cancer: from bench to bedside

           improvements in survival. We will still be unable to   DECLARATIONS
           determine which patients will benefit, without detailed
           longitudinal study of clinical tissues. Artificial cell line   Authors’ contributions
           models  of  “progression”  help  little  in  this  regard.  I   N.J. Maitland contributed solely to the paper.
           firmly believe that the future of cancer treatment lies
           in  a  patient/tumor-specific  strategy,  and  without  the   Financial support and sponsorship
           clinical material to back this up, from both an early   I wish to acknowledge  the ongoing  support of my
           stage in the treatment cycle, and after the almost   research in this area by grants from Prostate Cancer
           inevitable relapse, we are limiting our understanding   UK and Charity Soul.
           of  the  disease.  Every  man  appears  to  be  different
           in  his  responses,  although  there  are  some  over-  Conflicts of interest
           arching  changes  in  response  to  therapy.  The  “fatal   There are no conflicts of interest.
           lesion” provided at rapid autopsy has been a goal of
           some major centers in the USA. This is an expensive   Patient consent
           exercise, which often lacks both pre-treatment normal   Not applicable.
           tissues (chemotherapy affects all tissues in the patient,
           so a blood draw of lymphocytes from a patient after   Ethics approval
           extensive  chemotherapy  will  reflect  the  populations   Not applicable.
           which survived the treatment) and the treatment
           naïve cancers as comparators. The depth of analysis   REFERENCES
           of which we are now capable, simply demands better
           tissues to be used to their fullest capacity. It is these   1.   Chen W, Dong J, Haiech J, Kilhoffer MC, Zeniou M. Cancer stem
           very tumor biopsies, which scientists really require   cell quiescence and plasticity as major challenges in cancer therapy.
                                                                 Stem Cells Int 2016;2016:1740936.
           from the oncology community, not just from patients   2.   Frame FM, Pellacani D, Collins  AT, Simms MS, Mann  VM,
           referred to large research centers, but the “every    Jones GD, Meuth M, Bristow RG, Maitland NJ. HDAC inhibitor
           prostate cancer patient” samples, from truly standard   confers radiosensitivity to prostate stem-like cells.  Br J Cancer
           of care environments.                                 2013;109:3023-33.
                                                              3.   MacRae EJ, Giannoudis A, Ryan R, Brown NJ, Hamdy FC, Maitland
           CONCLUSION                                            N, Lewis CE. Gene therapy for prostate cancer: current strategies and
                                                                 new cell-based approaches. Prostate 2006;66:470-94.
                                                              4.   Gleason  DF.  Classification  of  prostatic  carcinomas.  Cancer
           For almost 40 years, a limited set of established     Chemother Rep 1966;50:125-8.
           prostate cancer cell lines have dominated basic    5.   Epstein JI.  An update of the Gleason grading system.  J Urol
           research in prostate cancers. Whilst they retain a    2010;183:433-40.
           number of key properties of the cancer in patients, they   6.   Epstein JI, Allsbrook WC Jr, Amin MB, Egevad LL; ISUP Grading
           represent prostate cancer in an era before androgen   Committee. The 2005 International Society of Urological Pathology
           therapies and targeted radiotherapy. In addition,     (ISUP) Consensus Conference  on Gleason grading of prostatic
           the cells from LNCaP, DU145 and PC3 have been      7.   carcinoma. Am J Surg Pathol 2005;29:1228-42.
                                                                 Gleason DF. Histologic grading of prostate cancer: a perspective.
           passaged repeatedly in different growth media and in   Hum Pathol 1992;23:273-9.
           immune-compromised mouse hosts. To study prostate   8.   Gundem G,  Van Loo P, Kremeyer B,  Alexandrov LB,  Tubio JM,
           cancer in the current decade we require models that   Papaemmanuil  E,  Brewer  DS, Kallio  HM, Hognas G,  Annala  M,
           represent contemporary disease.                       Kivinummi K, Goody V, Latimer C, O’Meara S, Dawson KJ, Isaacs
                                                                 W, Emmert-Buck MR, Nykter M, Foster C, Kote-Jarai Z, Easton D,
           By establishing a collaboration with the clinic, basic   Whitaker  HC; ICGC Prostate  Group, Neal  DE, Cooper CS, Eeles
           scientists can begin to ask the correct questions,    RA, Visakorpi T, Campbell PJ, McDermott U, Wedge DC, Bova GS.
                                                                 The evolutionary history of lethal metastatic prostate cancer. Nature
           whilst retaining the capacity to test mechanisms of   2015;520:353-7.
           action or hypotheses in appropriate established cell   9.   Huang J, Wang JK, Sun Y. Molecular pathology of prostate cancer
           lines. However, we should be framing our hypotheses   revealed  by next-generation  sequencing:  opportunities  for genome-
           in actual cancers, either in human tissue biopsies or   based personalized therapy. Curr Opin Urol 2013;23:189-93.
           primary cell cultures (or both). Using multiple primary   10.  Friedlander TW, Roy R, Tomlins SA, Ngo VT, Kobayashi Y, Azameera
           cultures or biopsies is the equivalent of an  in vitro   A, Rubin MA, Pienta KJ, Chinnaiyan A, Ittmann MM, Ryan CJ, Paris
           clinical  trial  for  new  drugs.  Only  by  embracing  the   PL. Common structural  and  epigenetic changes  in  the  genome  of
                                                                 castration-resistant prostate cancer. Cancer Res 2012;72:616-25.
           heterogeneity of the prostate cancer patient population   11.  Wyatt AW, Gleave ME. Targeting the adaptive molecular landscape of
           can  we  begin  to  approach  personalized,  effective   castration-resistant prostate cancer. EMBO Mol Med 2015;7:878-94.
           cancer medicine with  an ultimate goal of long-term   12.  Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg
           treatments for men with prostate cancer.              M, Cruz-Gordillo  P,  Francis  JM, Zhang  CZ,  Shalek AK, Satija  R,
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