Page 148 - Read Online
P. 148

Zhu et al.                                                                                                                                                  Function of Mcl-1 and its regulative relations with HCC

               induced apoptosis in hepatocellular carcinoma cells by transcriptional   S. Pyrogallol-based molecules as potent inhibitors of the antiapoptotic
               repression of Mcl-1. Cell Signal 2012;24:1803-9.  Bcl-2 proteins. J Med Chem 2007;50:1723-6.
           104. Zhu H, Yang W, He LJ, Ding WJ, Zheng L, Liao SD, Huang P, Lu   109. Tang G, Ding K, Nikolovska-Coleska Z, Yang CY, Qiu S, Shangary
               W, He QJ, Yang B. Upregulating Noxa by ER stress, celastrol exerts   S, Wang R, Guo J, Gao W, Meagher J, Stuckey J, Krajewski K, Jiang
               synergistic  anti-cancer  activity  in combination  with ABT-737 in   S, Roller PP, Wang S. Structure-based design of flavonoid compounds
               human hepatocellular carcinoma cells. PLoS One 2012;7:e52333.  as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2
           105. Wei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, Stebbins JL,   proteins. J Med Chem 2007;50:3163-6.
               Zhai D, Sun J, Yang L, Dahl R, Zhang Z, Wu B, Wang S, Reed TA,   110. Tang G, Nikolovska-Coleska Z, Qiu S, Yang CY, Guo J, Wang S.
               Wang HG, Lawrence N, Sebti S, Reed JC, Pellecchia M. Apogossypol   Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. J Med
               derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol   Chem 2008;51:717-20.
               Cancer Ther 2009;8:904-13.                     111. Chen KF, Su JC, Liu CY, Huang JW, Chen KC, Chen WL, Tai WT,
           106. Stein  RC, Joseph AE, Matlin  SA, Cunningham  DC, Ford HT,   Shiau CW. A novel obatoclax derivative, SC-2001, induces apoptosis
               Coombes RC. A preliminary clinical study of gossypol in advanced   in hepatocellular carcinoma cells through SHP-1-dependent STAT3
               human cancer. Cancer Chemother Pharmacol 1992;30:480-2.  inactivation. Cancer Lett 2012;321:27-35.
           107. Mi JX, Wang GF, Wang HB, Sun XQ, Ni XY, Zhang XW, Tang   112. Zhang Z, Song T, Zhang T, Gao J, Wu G, An L, Du G. A novel
               JM, Yang DJ. Synergistic  antitumoral  activity  and  induction  of   BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by
               apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with   targeting both Bcl-2 and Mcl-1. Int J Cancer 2011;128:1724-35.
               adriamycin in human hepatocellular carcinoma. Acta Pharmacol Sin   113. Furuse J, Okusaka  T,  Kaneko  S, Kudo M, Nakachi  K, Ueno H,
               2008;29:1467-77.                                  Yamashita T, Ueshima K. Phase I/II study of the pharmacokinetics,
           108. Tang G, Yang CY, Nikolovska-Coleska Z, Guo J, Qiu S, Wang R,   safety and efficacy of S-1 in patients with advanced hepatocellular
               Gao W, Wang G, Stuckey J, Krajewski K, Jiang S, Roller PP, Wang   carcinoma. Cancer Sci 2010;101:2606-11.
























































            140                                                                                                             Hepatoma Research ¦ Volume 3 ¦ July 06, 2017
   143   144   145   146   147   148   149   150   151   152   153