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Turati et al. Hepatoma Res 2022;8:19 https://dx.doi.org/10.20517/2394-5079.2021.130 Page 7 of 15

Figure 2. Bar plot for the age-standardized (world population) death rates of extrahepatic cholangiocarcinoma (ECC) around 2016,
ordered from the highest to the lowest rate, in men (A) and women (B).

Geographic variations in ECC mortality patterns were observed for women. The most recent highest rates
were registered in Japan and Hungary, as for men, although with lower values (1.19/100,000 and 1.06,
respectively) [Figure 2].

Table 2 gives the age-standardized mortality rates at ages 45-64 years. Over the two considered periods, ICC
mortality rates increased in most countries in both sexes. Around 2016, male rates from about 1.1/100,000