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Figure 1. Bar plot for the age-standardized (world population) death rates of intrahepatic cholangiocarcinoma (ICC) around 2016,
ordered from the highest to the lowest rate, in men (A) and women (B).

Around 2012, ECC male mortality rates among countries of the EU varied: 0.07/100,000 in France and
0.09/100,000 in Spain, 0.21/100,000 in Italy, 0.54/100,000 in Sweden, and 0.70/100,000 in Germany. Among
American countries, Brazil registered the highest rate (0.34/100,000), followed by the USA (0.11). Japan had
the highest rate, with 2.8 deaths per 100,000 men. Over the studied period, ECC mortality rates decreased in
most European and Australasian countries. In contrast, rates tended to increase in most American
countries, except in Brazil. Around 2016, ECC mortality rates were below 1/100,000 men in all countries,
with the exception of Japan and Hungary (2.57/100,000 and 1.48/100,000 men, respectively) [Figure 2].