Page 133 - Read Online

Tai et al. Hepatoma Res 2020;6:74 I http://dx.doi.org/10.20517/2394-5079.2020.54 Page 11 of 12

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

REFERENCES
1. Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a
systematic review of data published between 1965 and 2013. Lancet 2015;386:1546-55.
2. Chen CJ, Tai J, Tai DI. Hepatocellular carcinoma occurred in a Hepatitis B carrier clinic cohort during a mean follow up of 10 years.
Hepatoma Res 2019;5:25.
3. Yu MW, Chang HC, Liaw YF, et al. Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives. J
Natl Cancer Inst 2000;92:1159-64.
4. Burk RD, Hwang LY, Ho GY, Shafritz DA, Beasley RP. Outcome of perinatal hepatitis B virus exposure is dependent on maternal virus
load. J Infect Dis 1994;170:1418-23.
5. Tai DI, Chen CH, Chang TT, et al. Eight-year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: role of
viral infection. J Gastroenterol Hepatol 2002;17:682-9.
6. Chen CH, Chen YY, Chen GH, et al. Hepatitis B virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676
relatives with hepatocellular carcinoma. J Hepatol 2004;40:653-9
7. Tai DI, Tsay PK, Chen WT, Chu CM, Liaw YF. Relative roles of HBsAg seroclearance and mortality in the decline of HBsAg prevalence
with increasing age. Am J Gastroenterol 2010;105:1102-9.
8. Liaw YF, Tai DI, Chu CM, Chen TJ. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study.
Hepatology 1988;8:493-6.
9. Cardin R, Piciocchi M, Bortolami M, et al. Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: an
intricate pathway. World J Gastroenterol 2014;20:3078-86.
10. Liu WC, Wu IC, Lee YC, et al. Hepatocellular carcinoma-associated single-nucleotide variants and deletions identified by the use of
genome-wide high-throughput analysis of hepatitis B virus. J Pathol 2017;243:176-92.
11. Zhang Z, Wang C, Liu Z, et al. Host genetic determinants of hepatitis B virus infection. Front Genet 2019;10:696.
12. Akcay IM, Katrinli S, Ozdil K, Doganay GD, Doganay L. Host genetic factors affecting hepatitis B infection outcomes: insights from
genome-wide association studies. World J Gastroenterol 2018;24:3347-60.
13. Zhu H, Wu J, Shen X. Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes.
Scand J Gastroenterol 2017;52:209-15.
14. Hai H, Tamori A, Kawada N. Role of hepatitis B virus DNA integration in human hepatocarcinogenesis. World J Gastroenterol
2014;20:6236-43.
15. 1000 Genomes Project Consortium, Auton A, Brooks LD, et al. A global reference for human genetic variation. Nature 2015;526:68-74.
16. Xia GL, Liu CB, Cao HL, et al. Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a
nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992. Int Hepatol Comm
1996;5:62-73.
17. Kamatani Y, Wattanapokayakit S, Ochi H, et al. A genome-wide association study identifies variants in the HLA-DP locus associated with
chronic hepatitis B in Asians. Nat Genet 2009;41:591-5.
18. Mbarek H, Ochi H, Urabe Y, et al. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese
population. Hum Mol Genet 2011;20:3884-92.
19. Hu Z, Liu Y, Zhai X, et al. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nat Genet 2013;45:1499-503.
20. Nishida N, Sawai H, Matsuura K, et al. Genome-wide association study confirming association of HLA-DP with protection against
chronic hepatitis B and viral clearance in Japanese and Korean. PLoS One 2012;7:e39175.
21. Kim YJ, Kim HY, Lee JH, et al. A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
Hum Mol Genet 2013;22:4233-8.
22. Al-Qahtani AA, Al-Anazi MR, Abdo AA, Sanai FM, Al-Hamoudi W, et al. Association between HLA variations and chronic hepatitis B
virus infection in Saudi Arabian patients. PLoS One 2014;9:e80445.
23. Chang SW, Fann CS, Su WH, et al. A genome-wide association study on chronic HBV infection and its clinical progression in male Han-
Taiwanese. PLoS One 2014;9:e99724.
24. Tai DI, Jeng WJ, Lin CY. A global perspective on HBV-related SNPs and evolution during human migration. Hepatol Commun
2017;1:1005-13.
25. Liaw YF, Chu CM. Hepatitis B virus infection. Lancet 2009;373:582-92.
26. Chang MH, Hsu HY, Hsu HC, et al. The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special