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Sun et al. Vessel Plus 2020;4:13 I http://dx.doi.org/10.20517/2574-1209.2020.02 Page 11 of 13

consideration of blood flow rheology, predictive models of peak wall stress in AAA would be more accurate
and complete.

In conclusion, to be more precise and specific in evaluating the risk of rupture in AAA, the present study
developed a new prediction method (predictive equations) that included more patient sex and AAA
morphology, based on quantitative biomechanical simulation. Results revealed that the risk of an AAA
rupture is not only related to morphological factors, but sex differences as well. This study provides a sex-
specific clinical reference tool to assess the aforementioned risk. Future studies should integrate more
information from simulation and imaging technologies.

DECLARATIONS
Acknowledgments
The English was edited and improved by Dominique Fournier, and the authors sincerely thank him
profusely for the quality of his contribution and his patience.

Authors’ contributions
Conception and design: Sun AQ, Zhang YX
Data acquisition: Zhang YX
Analysis and interpretation of data: Sun AQ, Guidoin R, Zhang YX
Supervised the work: Sun AQ, Deng XY
Drafted the manuscript: Sun AQ, Zhang YX, Guidoin R, Xu ZP
Sustancially revised the manuscript: Sun AQ, Ren SQ, Zhang YX
Approved the manuscript: Sun AQ, Zhang YX, Xu ZP, Ren SQ, Deng XY, Guidoin R

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by the National Natural Science Foundation of China (No. 11872096, 11772036,
31870940, 11862004), the “111” Project (B13003).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

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