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Bobronnikova. Vessel Plus 2017;1:61-7 Vessel Plus
DOI: 10.20517/2574-1209.2016.10
www.vpjournal.net
Original Article Open Access

Galectin-3 as a potential biomarker of

metabolic disorders and cardiovascular

remodeling in patients with hypertension

and type 2 diabetes

Lesya Bobronnikova

Department of Clinical Pharmacology, Kharkiv National Medical University, 61000 Kharkiv, Ukraine.
Correspondence to: Prof. Lesya Bobronnikova, Head of Department of Clinical Pharmacology, Kharkiv National Medical University, 2A Postysheva
Avenue, 61000 Kharkiv, Ukraine. E-mail: l.bobronnikova@mail.ru
How to cite this article: Bobronnikova L. Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with
hypertension and type 2 diabetes. Vessel Plus 2017;1:61-7.

Prof. Lesya Bobronnikova received her doctorate in 2009. She is an author and co-author of publications in
international journals on metabolic syndrome, hypertension and diabetes. Currently, she is Head of the Department of
Clinical Pharmacology at the Kharkov National Medical University, the clinical basis of which is located on the territory
of the L. T. Malaya National Therapy Institute of NAMS of Ukraine. At the moment, the department is involved in
research work on optimization of diagnosis and treatment of combined arterial hypertension and gene polymorphism
dependent diabetes mellitus type 2. Prof. Lesya Bobronnikova invites all scientists interested in the subject of our
research work for international cooperation.
ABSTRACT

Article history: Aim: To determine the impact of galectin-3 levels on the progression of metabolic disorders
Received: 26-10-2016 and structural-functional changes in the myocardium and blood vessels in patients with
Accepted: 08-05-2017 concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM).
Published: 27-06-2017 Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females)
were examined. The patients were separated: group 1 (n = 32) patients with AH, without
Key words: carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group
Arterial hypertension, 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate metabolism, insulin resistance
type 2 diabetes mellitus, parameters and galectin-3 levels were measured. Echocardiography was performed to
insulin resistance, determine the structural-functional condition of the heart. Estimation of the intima-media
cardiovascular remodeling, complex thickness of the common carotid artery was performed by duplex ultrasound scanning.
galectin-3 Results: Hypertrophy of the left ventricular myocardium is most evident in patients with AH
and type 2 DM compared with groups 1 and 2, and the control group (P < 0.05). The levels
of galectin-3 in the group with concomitant hypertension and type 2 DM were higher than in
groups 1 and 2, and the control group (P < 0.05). A positive correlation was revealed between
the level of galectin-3, indices of insulin resistance, and structural-functional cardiac and vessel
remodeling. Conclusion: Galectin-3 levels in serum are significantly linked with indices of
insulin resistance and cardiovascular remodeling.

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