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Todua et al. Vessel Plus 2017;1:38-42 Vessel Plus
DOI: 10.20517/2574-1209.2016.06
www.vpjournal.net
Short Communication Open Access

Homocysteine and D-dimer levels and

multilayer computed tomography for diagnosing

pulmonary artery thromboembolism

Fridon Todua, Manana Akhvlediani, Elena Vorobiova, Giorgi Tsivtsivadze, Anna Baramidze

Research Institute of Clinical Medicine, 0112 Tbilisi, Georgia.
Correspondence to: Prof. Manana Akhvlediani, Research Institute of Clinical Medicine, 13, Tevdore Mgvdeli Street, 0112 Tbilisi, Georgia. E-mail:
m_akhvlediani2000@hotmail.com

How to cite this article: Todua F, Akhvlediani M, Vorobiova E, Tsivtsivadze G, Baramidze A. Homocysteine and D-dimer levels and multilayer
computed tomography for diagnosing pulmonary artery thromboembolism. Vessel Plus 2017;1:38-42.

Prof. Manana Akhvlediani is scientific head of Laboratory of Clinical Biochemistry of Research Institute of Clinical
Medicine. She received her PhD in biochemistry of atherosclerosis. She is Associated Professor and local head
of postgraduate study program in Laboratory Medicine of Georgian Medical University, Tbilisi. She participates in
several clinical trials.

ABSTRACT
Article history: Aim: D-dimer reportedly plays a leading role in diagnosing pulmonary embolism.
Received: 17-10-2016 Additionally, homocysteine is an established risk factor for atherosclerosis, vascular disease,
Accepted: 29-12-2016 and thrombosis. Herein, the authors aimed to evaluate the diagnostic significance of D-dimer
Published: 31-03-2017 and homocysteine levels, together with multi-detector computed tomography (CT) in suspected
pulmonary embolism. Methods: The authors examined patients suffering from conditions and
complaints that are typical of pulmonary artery thromboembolism (PATE), such as chest pain,
Key words: haemoptysis, dyspnoea, tachycardia, arterial hypotension, and signs of vein thrombosis in the
Homocysteine, inferior limbs. In these patients, PATE was found in different localizations with varying rates of
D-dimer, severity. D-dimer levels were measured in patients with suspected PATE using enzyme-linked
pulmonary embolism
immunosorbent assays. Homocysteine levels were determined by an enzymatic method. All
patients were examined to evaluate the presence of pulmonary embolism by multi-detector
CT angiopulmonography. Results: Changes in homocysteine levels can be considered a
separate independent factor for PATE diagnostics. The correlation between multi-detector
CT angiopulmonography, elevated D-dimer levels, and concomitant hyperhomocysteinemia
can be used not only for diagnostics but also for the assessment of the effectiveness of PATE
treatment. Conclusion: Multi-detector CT angiopulmonography, D-dimer levels and related
hyperhomocysteinemia can serve as significant laboratory markers in the diagnosis and
treatment efficacy of PATE.
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