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Singh et al. Vessel Plus 2017;1:213-29 Vessel Plus
DOI: 10.20517/2574-1209.2017.26
www.vpjournal.net
Review Open Access

An overview of different methods of

myocardial protection currently employed

peri-transplantation

Sanjeet Singh Avtaar Singh , Sudeep Das De , Cristiano Spadaccio , Colin Berry , Nawwar Al-Attar 1
2,3
1
1,3
1
1 Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow G81 4DY, UK.
2 Department of Cardiology, Golden Jubilee National Hospital, Glasgow G81 4DY, UK.
3 Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow G81 4DY, UK.
Correspondence to: Mr. Sanjeet Singh Avtaar Singh, Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow G81 4DY, UK.
E-mail: sanjeetsingh@nhs.net
How to cite this article: Singh SSA, Das De S, Spadaccio C, Berry C, Al-Attar N. An overview of different methods of myocardial protection
currently employed peri-transplantation. Vessel Plus 2017;1:213-29.

Mr. Sanjeet Singh Avtaar Singh, MBChB (Edin), MSc (Edin), MRCS (Edin), is a cardiothoracic research fellow
who is currently the Cardiothoracic Advisory Group (CTAG) Audit Fellow based in Scotland at the Golden Jubilee
National Hospital. He is currently pursuing his PhD at the University of Glasgow. His research interests surround
primary graft dysfunction in heart transplantation.

ABSTRACT
Article history: Myocardial protection is integral to the functioning of hearts in day to day cardiac surgery.
Received: 26 Jul 2017 However, due to the longer ischaemic times, it becomes pivotal in the management of organs
First Decision: 7 Sep 2017 during transplantation. There are many different strategies employed to ensure diligent and
Revised: 17 Sep 2017 judicious myocardial protection during donor management, transportation of the heart and the
Accepted: 20 Sep 2017 post-operative period. Given the limited supply of organs and the increasing waiting lists for
Published: 28 Dec 2017 heart transplants worldwide, it has become an area of renewed interest with many innovations
and inventions using the principles of basic sciences to improve outcomes of transplanted
Key words: hearts. The heart procurement process encompasses several of the different myocardial
Myocardial protection, protection strategies in tandem to provide the greatest benefit to the recipients. This review
cardiac surgery,
cardiac transplantation looks at the different modalities employed, which include different types of cardioplegia,
the role of biomarkers, the cutting-edge novel therapies, hormonal therapies and ischaemic
conditioning strategies.

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