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Gowdar et al. Diabetes mellitus and takotsubo cardiomyopathy

the pathophysiological basis of TC. It would be pathophysiologic connotations. Eur Heart J Acute Cardiovasc Care
extremely informative if future case series, case 2016;5:164-70.
reports and TC registries maintain and report more 6. Khalid N, Chhabra L. Takotsubo cardiomyopathy and microcirculatory
detailed information about the diabetes status of TC 7. dysfunction. Nat Rev Cardiol 2015;12:497.
Khalid N, Ahmad SA, Umer A. Coronary flow reserve assessment via
patients. Details like type of DM, chronicity, use of oral invasive and noninvasive means in Takotsubo cardiomyopathy. Int J
hypoglycemic agents, use of insulin, HbA1c values, Cardiol 2016;202:573.
uncomplicated, complicated by dysautonomia, chronic 8. Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone
kidney disease, microvascular disease and presence E, Cacciotti L, Capucci A, Citro R, Delmas C, Guerra F, Ionescu
of end organ damage need to be collected to further CN, Lairez O, Larrauri-Reyes M, Lee PH, Mansencal N, Marazzi
study the association between TC and DM. Future G, Mihos CG, Morel O, Nef HM, Nunez Gil IJ, Passaseo I, Pineda
studies also need to highlight the presence of other co- AM, Rosano G, Santana O, Schneck F, Song BG, Song JK, Teh AW,
Ungprasert P, Valbusa A, Wahl A, Yoshida T, Gaudio C, Kaski JC.
morbities like hypertension, dyslipidemia and coronary Comorbidities frequency in Takotsubo syndrome: an international
microvascular dysfunction and their interaction with collaborative systematic review including 1109 patients. Am J Med
diabetes to better elucidate the effect of DM in the 2015;128:654.e11-9.
pathogenesis of TC. 9. Núñez-Gil IJ, Almendro-Delia M, Andrés M, Sionis A, Martin A,
Bastante T, Córdoba-Soriano JG, Linares JA, González Sucarrats S,
DECLARATIONS Sánchez-Grande-Flecha A, Fabregat-Andrés O, Pérez B, Escudier-
Villa JM, Martin-Reyes R, Pérez-Castellanos A, Rueda Sobella F,
Authors’ contributions Cambeiro C, Piqueras-Flores J, Vidal-Perez R, Bodí V, García de la
Villa B, Corbí-Pascua M, Biagioni C, Mejía-Rentería HD, Feltes G,
Did literature review and composed the first draft of the Barrabés J; RETAKO investigators. Secondary forms of Takotsubo
article: S. Gowdar cardiomyopathy: a whole different prognosis. Eur Heart J Acute
Reviewed data and worked on the subsequent Cardiovasc Care 2016;5:308-16.
revisions: S. Syal 10. Madias JE. Diabetes mellitus and Takotsubo syndrome in two Spanish
cohorts. Eur Heart J Acute Cardiovasc Care 2016;5:297.
Conceptualized the study design, reviewed progress 11. Khalid N, Iqbal I, Coram R, Raza T, Fahsah I, Ikram S. Thrombolysis
of the article at each step, and finalized the manuscript in myocardial infarction frame count in takotsubo cardiomyopathy.
of the review article: L. Chhabra Int J Cardiol 2015;191:107-8.
12. Brinjikji W, El-Sayed AM, Salka S. In-hospital mortality among
Financial support and sponsorship patients with takotsubo cardiomyopathy: a study of the National
None. Inpatient Sample 2008 to 2009. Am Heart J 2012;164:215-21.
13. Patel SM, Chokka RG, Prasad K, Prasad A. Distinctive clinical
characteristics according to age and gender in apical ballooning
Conflicts of interest syndrome (takotsubo/stress cardiomyopathy): an analysis focusing on
There are no conflicts of interest. men and young women. J Card Fail 2013;19:306-10.
14. Dias A, Franco E, Rubio M, Koshkelashvili N, Bhalla V, Amanullah
Patient consent S, Hebert K, Figueredo VM. Takotsubo syndrome: does it matter if
you have diabetes mellitus? Int J Cardiol 2016;224:398-9.
Not applicable. 15. Auzel O, Mustafic H, Pillière R, El Mahmoud R, Dubourg O,
Mansencal N. Incidence, characteristics, risk factors, and outcomes of
Ethics approval takotsubo cardiomyopathy with and without ventricular arrhythmia.
Not applicable. Am J Cardiol 2016;117:1242-7.
16. Khera R, Light-McGroary K, Zahr F, Horwitz PA, Girotra S. Trends
in hospitalization for takotsubo cardiomyopathy in the United States.
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