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Verriello et al. Vessel Plus 2021;5:51 Vessel Plus
DOI: 10.20517/2574-1209.2021.69

Review Open Access

Interpreting signals from the peripheral nerve in

amyloidosis: a call for action

Lorenzo Verriello, Chiara Dalla Torre, Giada Pauletto, Gian Luigi Gigli
Neurology Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, ASUFC, Udine 33100, Italy.

Correspondence to: Dr. Lorenzo Verriello, Neurology Unit, Department of Neurosciences, Santa Maria della Misericordia
University Hospital, ASUFC, Piazzale Santa Maria della Misericordia 15, Udine 33100, Italy.
E-mail: lorenzo.verriello@asufc.sanita.fvg.it

How to cite this article: Verriello L, Dalla Torre C, Pauletto G, Gigli GL. Interpreting signals from the peripheral nerve in
amyloidosis: a call for action. Vessel Plus 2021;5:51. https://dx.doi.org/10.20517/2574-1209.2021.69
Received: 30 Apr 2021 First Decision: 15 Jun 2021 Revised: 30 Jun 2021 Accepted: 21 Jul 2021 First online: 21 Jul 2021

Academic Editors: Gianfranco Sinagra, Narasimham L. Parinandi Copy Editor: Yue-Yue Zhang Production Editor: Yue-Yue
Zhang

Abstract
Systemic amyloidosis includes a group of disorders, characterized by deposition of insoluble aggregates of amyloid
fibrils in various tissues that lead to disruption of normal tissue structure and impaired function. They are currently
categorized as hereditary and secondary. Peripheral neuropathy is a frequent complication of systemic amyloidosis.
The most common phenotype is a length-dependent sensorimotor polyneuropathy with autonomic dysfunction,
but there are many atypical presentations that often lead to delayed diagnosis. In this review, we emphasize the
neurological clinical aspects that induce a suspicion of amyloidosis, the possible differential diagnosis and the
diagnostic pitfalls. An early diagnosis of the disease is crucial for rapid initiation of appropriate treatment that may
change the course and the progression of the disease.

Keywords: Amyloidosis, neuropathy, transthyretin

INTRODUCTION
Systemic amyloidosis includes a heterogeneous group of disorders, characterized by the accumulation of
[1]
amyloid fibrils in different tissues, leading to structure disruption and impaired function .

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
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