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Barioli et al. Vessel Plus 2024;8:13 https://dx.doi.org/10.20517/2574-1209.2023.68 Page 9 of 14

Table 2. Most representative studies on outcomes of coronary artery aneurysms patients undergoing different percutaneous
interventions
Study sample size Follow-
First author, and population Study up Outcomes Measure of effect and/or P- Comments
year characteristics design length values

Schram et al., 77 no-reflow STEMI Case-control N/A No reflow post-PPCI CAE frequency higher in no- CAE remained a
[58]
2018 pts vs. 154 with TIMI study reflow pts (33.8% vs. 3.9%; strong independent
flow ≥ 2 after PPCI. P < 0.001). CAE pts less often predictor of no-
32 pts with Ectatic underwent stenting and reflow at
IRA experienced more no-reflow multivariate
(25.6% vs. 81.3%; P < 0.001) analysis
Fujii et al., 39 STEMI pts with Retrospective 775 days Post-PPCI TIMI flow. Higher TIMI flow ≤ 2 in the
2017 [59] Ectatic IRA vs. 705 30-day and 1-year all- Ectatic IRA group (46.2% vs.6.5%;
pts with non-Ectatic cause death P < 0.0001)
IRA All-cause 30-day and 1-year
death was lower in the Ectatic
group (0% vs. 9.4%; P = 0.045
and 2.6% vs. 14.5%; P = 0.036,
respectively)
Abdelfattah 41 pts with TCE (2 Retrospective 10 Successful Successful angiographic closure
et al., CAA, 2 CAPA) months angiographic closure; in 87.8% of cases (100% of CAA
2021 [60] adverse events related and CAPA patients). No TCE-
to tce; mortality related adverse events in
CAA/CAPA pts. 1 CAA patient
died from respiratory failure
42 days after the procedure
Wu et al., 33 pts with CAA and Retrospective 1 year Reduction of CAA MLD and DS improved right No clinical events
2020 [61] stenosis > 60%, size, MLD, and DS after PCI (P < 0.01). TIMI flow reported at 1-year
treated with DES after PCI, and 1 year grade was enhanced after PCI f/u
thereafter (P < 0.01). At 1-year f/u, maximal
CAA diameter was reduced
compared with that just after PCI
(P < 0.01)
Parikh et al., 32 pts treated with Retrospective 49 TLR, ISR, all-cause Neither in-hospital or 30-day
2019 [62] PTFE CCS (24 CAP, months mortality mortality nor evidence of TLR at
8 CAA) f/u. All-cause mortality was 12%
at 1 year and 38% at 3 years
Hachinohe 190 pts treated with Retrospective 6.0 years TV-MI, TVO, TLR, ST, TLF lower in CAA than in SVG
et al., CCS for SVG cardiac death (P = 0.023). Higher TVO, TV-MI,
[63]
2019 (51.4%), CAP and ST in pts with CAP
(25.0%), and CAA (P = 0.010, 0.047, and 0.046,
(11.8%) respectively)
TVO rate was highest in pts with
SVG (43.8% at 10 years)
No differences in TLR and
cardiac death between groups
Joo et al., 78 CAA pts vs. 269 Retrospective 16.1 MACE (all-cause CAA patients had higher MACE Analyses after PSM
2018 [6] non-CAA pts after months death, nonfatal MI (26.9% vs. 2.2%; P < 0.01), showed similar
DES implantation and TLR) driven by nonfatal MI and TVR. results
ST was higher in the CAA group
(12.8 vs. 0.74%,P < 0.001)
Yip et al., 24 STEMI pts with Retrospective 19 In-hospital outcomes No-flow, cardiogenic shock, and Post-PCI distal
[64]
2002 aneurysmal IRA months and survival at 19 ± 30 in-hospital death rates were embolization in
months f/u 62%, 25%, and 8.3%, 70.8% of pts with
respectively. Survival at f/u was aneurysmal IRA
90.9%
Briguori et al., 7 pts with CAA Retrospective 35 In-hospital outcomes, Angiographic success in 100%
2002 [65] treated with PTFE months and MACE at f/u of cases
CCS 1 (14%) MACE event (TVR)
Iannopollo 32 STEMI pts with Retrospective 1 year Primary outcome (all- CAA as CL in STEMI was Primary endpoint
et al., CAA as CL vs. 2280 cause death and independently associated with was driven by MI
[5]
2017 STEMI pts without recurrent MI). primary outcome (HR: 2.24; due to higher rates
CAA as CL treated Definite ST 95%CI: 1.02-5.39; P = 0.04) and of ST
with PPCI ST (HR: 6.29; 95%CI: 2.32-
17.05; P < 0.001)
Djohan et al., 36 STEMI pts with Retrospective 3 years MACE (all-cause At 3 years, all-cause mortality CAE pts had more
[66]
2022 CAE vs. 1816 STEMI mortality, MI, was significantly more frequent RCA involvement,
non-CAE unplanned in the non-CAE group (0.0% vs. less coronary