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Page 6 of 34 Bai et al. Soft Sci 2023;3:40 https://dx.doi.org/10.20517/ss.2023.38
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Figure 2. Biocompatibility assay of LMNPs. (A) Cellular level. (i) Survival under different nanomaterials in culture , symbols indicate
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all cells died; (ii) Survival of MCF-7 cells cultured at different concentrations of molecularly grafted LMNPs ; (B) Tissue level.
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Histological characterization of impact of LMNPs to major organs ; (C) Organ level. Liver function indicators in mice after injection of
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45 mg·kg LMNPs . (i) ALT, ALP, and AST levels; (ii) albumin concentrations; and (iii) BUN measured at different times in LM-NP/L
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blood; (D) Biological level. (i) Survival of mice injected with LMNPs over time ; (ii) Determination of gallium in stool and urine of mice
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after injection of LMNPs ; (iii) Changes in body weight of mice after injection of different types of LMNPs . ALP: Alkaline
phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; bPEG: brushed polyethylene glycol; BUN: blood urea
nitrogen; LM: liquid metal; LMNPs: LM nanoparticles; MWCNT: multi-walled carbon nanotube; OA: oleic acid; PMVEMA: poly methyl
vinyl ether-alt-maleic anhydride; PSMA: poly styrene-co-maleic anhydride.
The results of Alamar Blue experiments showed that the survival of MCF-7 cells under the conditions of
