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Lin et al. Plast Aesthet Res 2019;6:16 I http://dx.doi.org/10.20517/2347-9264.2019.23 Page 9 of 10

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by Regen Biotech, Inc., Seoul, South Korea.

Conflicts of interest
Dr. Dae-Yeol Yang has no conflicts to disclose. Dr. Chuan-Yuan Lin is medical director for Regen. Dr. Jui-
Yu Lin is chief medical director for Regen. Dr. Seong-Ho Lee has no conflicts to disclose. Miyeon Kang is
director for Regen R&D center. Dr. Jeoung-Yong Kim is chief director for Regen R&D center.

Ethical approval and consent to participate
The study has been approved by relevant ethical committee and the whole research process complied with
ethical guidelines.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

REFERENCES
1. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000;21:2335-46.
2. Kulkarni RK, Pani KC, Neuman C, Leonard F. Polylactic acid for surgical implants. Arch Surg 1966;93:839-43.
3. Achtnich A, Forkel P, Metzlaff S, Zantop T, Petersen W. Degradation of poly-D-L-lactide (PDLLA) interference screws (Megafix (R)).
Arch Orthop Trauma Surg 2014;134:1147-53.
4. Farah S, Anderson DG, Langer R. Physical and mechanical properties of PLA, and their functions in widespread applications - a
comprehensive review. Adv Drug Deliv Rev 2016 15;107:367-92.
5. Saini P, Arora M, Kumar M. Poly(lactic acid) blends in biomedical applications. Adv Drug Deliv Rev 2016;107:47-59.
6. Athanasiou KA, Niederauer GG, Agrawal CM. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/
polyglycolic acid copolymers. Biomaterials 1996;17:93-102.
7. Pretula J, Slomkowski S, Penczek S. Polylactides-Methods of synthesis and characterization. Adv Drug Deliv Rev 2016;107:3-16.
8. Grandfils C, Flandroy P, Nihant N, Barbette S, Jerome R, et al. Preparation of poly (D,L) lactide microspheres by emulsion-solvent
evaporation, and their clinical applications as a convenient embolic material. J Biomed Mater Res 1992;26:467-79.
9. Robinson BP, Hollinger JO, Szachowicz EH, Brekke J. Calvarial bone repair with porous D,L-polylactide. Otolaryngol Head Neck Surg
1995;112:707-13.
10. Sherwood JK, Riley SL, Palazzolo R, Brown SC, Monkhouse DC, et al. A three-dimensional osteochondral composite scaffold for
articular cartilage repair. Biomaterials 2002;23:4739-51.
11. Valantin MA, Aubron-Olivier C, Ghosn J, Laglenne E, Pauchard M, et al. Polylactic acid implants (New-Fill) to correct facial lipoatrophy
in HIV-infected patients: results of the open-label study VEGA. AIDS 2003;17:2471-7.
12. Humble G, Mest D. Soft tissue augmentation using sculptra. Facial Plast Surg 2004;20:157-63.
13. Palm MD, Woodhall KE, Butterwick KJ, Goldman MP. Cosmetic use of poly-l-lactic acid: a retrospective study of 130 patients. Dermatol
Surg 2010;36:161-70.
14. Attenello NH, Maas CS. Injectable fillers: review of material and properties. Facial Plast Surg 2015;31:29-34.
15. Sanchez-Carpintero I, Candelas D, Ruiz-Rodriguez R. Dermal fillers: types, indications, and complications. Actas Dermosifiliogr
2010;101:381-93.
16. Breithaupt A, Fitzgerald R. Collagen stimulators: poly-L-Lactic acid and calcium hydroxyl apatite. Facial Plast Surg Clin North Am
2015;23:459-69.
17. Cho ER, Kang SW, Kim BS. Poly(lactic-co-glycolic acid) microspheres as a potential bulking agent for urological injection therapy:
preliminary results. J Biomed Mater Res B Appl Biomater 2005;72:166-72.
18. Kang SW, Cho ER, Kim BS. PLGA microspheres in hyaluronic acid gel as a potential bulking agent for urologic and dermatologic
injection therapies. J Microbiol Biotechnol 2005;15:510-8.
19. Cho ER, Kang SW, Park HJ, Cho YS, Lee YS, et al. Submucosal injection of poly(lactic-co-glycolic acid) microspheres in rabbit bladder
as a potential treatment for urinary incontinence and vesicoureteral reflux: preliminary results. J Biomater Sci Polym Ed 2005;16:1109-20.
20. Kang SW, Cho ER, Jeon O, Kim BS. The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking