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Orgun et al. Regenerative mechanisms of adipose-derived stem cells

etc.

Figure 2: The interaction between ASCs and M2 macrophages. ASCs: adipose-derived stem cells; VEGF: vascular endothelial growth
factor; bFGF: basic fibroblast growth factor; HGF: hepatocyte growth factor; IL-10: interleukin-10

Kim et al. [67] showed that ASCs conditioned media Authors’ contributions
promotes dermal fibroblast proliferation, suggesting Manuscript’s preparation: D. Orgun
the paracrine activation of fibroblasts by ASCs. The Manuscript’s review: H. Mizuno
same fibroblasts cultured in ASCs conditioned media Concept and design: H. Mizuno
were found to secrete increased amounts of type I Literature search: D. Orgun
collagen, and their expression of ECM proteins were
found to be augmented.These findings suggest that Financial support and sponsorship
this interaction might be playing an important role in
wound healing. None.
Conflicts of interest
SUMMARY
There are no conflicts of interest.
Many tissues have “intrinsic” stem cells in a resting
state, activated with injury in order to repair the Patient consent
damage. However, the number of these cells is usually Not applicable.
very small for complete regeneration by differentiating
into the harmed cell lines. Recent investigations Ethics approval
suggest that most stem cell lines also secrete
potent growth factors, and this indirect “paracrine” All the procedures followed were in accordance with
or “bystander” effect could be as important as their the ethical standards of the responsible com-mittee on
ability to differentiate in tissue regeneration. [68] There human experimentation (institutional or regional) and
is convincing evidence that the paracrine secretions by with the Helsinki Declaration when reporting studies on
ASCs improve wound healing and angiogenesis. The human beings.
data that we have obtained in our lab over the years
in several experiments also suggest that the paracrine REFERENCES
secretions of ASCs are extremely potent. We believe 1. Becker AJ, McCulloch EA, Till JE. Cytological demonstration of
that an accurate knowledge of ASCs secretome and its the clonal nature of spleen colonies derived from transplanted mouse
effects will help us to establish ASCs as a more viable marrow cells. Nature 1963;197:452-54.
clinical therapy in the future. 2. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P,
38 Plastic and Aesthetic Research ¦ Volume 4 ¦ March 22, 2017