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Horch et al. Plast Aesthet Res 2017;4:185-9                                        Plastic and
           DOI: 10.20517/2347-9264.2017.72
                                                                                  Aesthetic Research

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           Towards the future of plastic surgery: from

           flaps to microsurgery and regenerative

           medicine and biofabrication?



           Raymund E. Horch , Annika Weigand , Harald Wajant , Ran An , Jia-Min Sun , Andreas Arkudas
                                                         2
                                                                             3
                                                                                              1
                                                                1,3
                           1
                                           1
           1 Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital Erlangen,
           Friedrich-Alexander University Erlangen-Nuernberg FAU, 91054 Erlangen, Germany.
           2 Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Würzburg, Julius-Maximilians-Universität
           Würzburg, 97070 Würzburg, Germany.
           3 Union Plastic and Aesthetic Hospital, Huazhong University of Science and Technology, Wuhan Union Hospital, Wuhan 430022, Hubei, China.
           Correspondence to: Prof. Raymund E. Horch, Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative
           Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuernberg FAU, 91054 Erlangen, Germany.
           E-mail: Raymund.horch@uk-erlangen.de
           How to cite this article: Horch RE, Weigand A, Wajant H, An R, Sun JM, Arkudas A. Towards the future of plastic surgery: from flaps to microsurgery
           and regenerative medicine and biofabrication? Plast Aesthet Res 2017;4:185-9.
           Article history:  Received: 28 Sep 2017      Accepted: 19 Oct 2017      Published: 31 Oct 2017

           Plastic surgery is a specialty  that is now  worldwide   procedures (even before the  advent of  anaesthesia)
           recognized as  its  own academic discipline  within   today axially  vascularized  and  perforator  based
           the  surgical community. The roots however are     flaps  have  replaced  these  often  tedious  and  painful
           as  old  as  600  BC when  in  the Sushruta  Ayurveda   techniques. It was the publication of the Indian method
           the  reconstruction  of  a  nose  with  a  flap  from  the   of nose reconstruction in the Gentlemen´s magazine in
           forehead was described. Plastic surgery is a problem   England that replaced the random pattern flap based
           solving discipline  that meanwhile  is an integral   method that was described in Tagliacozzi’s two volume
           part within modern surgical concepts. A  number of   book De Curtorum Chirurgia per Insitionem (1597),
           groundbreaking  inventions and developments from   where he detailed the different surgical  steps with
           plastic  surgery  had led  to relevant  innovations  and   graphic illustrations that became a hallmark of surgical
           these influenced the whole field of surgical specialities,   textbooks ever since.
           including the nobel prize for the first successful renal
           transplantation, performed by the plastic surgeon   When within the last decades the rapid development of
           John Murray. Although principal  details of  operation   microsurgery allowed for transplantation of vascularized
           techniques that  had been described as early as    tissue to almost any part of the body this spread as
           600 BC are still part of the surgical armamentarium,   a fascinating  extension  of older  surgical  methods
           many innovative methods have enriched  the current   to many other surgical specialities as well. Modern
           spectrum of possibilities.  Whereas over many      reconstructive  and oncological  concepts rely on the
           centuries techniques of reconstruction utilized delayed   interdisciplinary  character  of plastic  surgery  making
           pedicled random pattern flaps and needed multi stage   our specialty  an essential  part of any reconstructive

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