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Table 1: Radical brachytherapy for oral cavity squamos cell carcinoma only, not including other head and neck sites
Studies No. of Site Technique Radiotherapy schedule 5-year local 5-year survival (%)
patients control (%)
[12]
Lau et al. 1996 27 Tongue HDR BT only, 45.5 Gy @6.5 Gy 53 92
[22]
Leung et al. 2002 19 Tongue HDR BT only, 45-63 Gy (median 55 Gy, ten 94.7 (4-year) NS
fracions)
[23]
Martínez-Monge et al. 8 Oral cavity HDR EBRT 45 + BT 16 Gy @4 Gy 86 (7-year) 52.3 (7-year)
2009
Guinot et al. 2010 33 Tongue HDR EBRT 55 + BT 18 Gy @3 Gy 79 74
[24]
17 Tongue HDR BT only 44 Gy @4 Gy
[28]
Inoue et al. 2001 25 Tongue HDR BT only 60 Gy @6 Gy 87
26 LDR BT only 70 Gy 84
[29]
Yamazaki et al. 2003 58 Tongue HDR BT only 60 Gy @6 Gy 84
341 LDR BT only 70 Gy 80
[30]
Yamazaki et al. 2007 80 Tongue HDR EBRT 37 Gy + BT 36-60 Gy 85
226
217 LDR Ra EBRT 29 Gy + BT 59-94 Gy 74
192
351 LDR Ir EBRT 29 Gy + BT 59-94 Gy 72
[32]
Kakimoto et al. 2011 14 Tongue (T3) HDR EBRT 30 Gy + 60 Gy 71 (2-year)
61 LDR EBRT 30 Gy + 72 Gy 62
Akiyama et al. [33] 2012 17 Tongue HDR BT only 54 Gy @ 6 Gy 88
34 BT only 60 Gy @6 Gy 88
[34]
Donath et al. 1995 13 Oral cavity HDR BT only 45-50 Gy @4.5-5 Gy 92
[35]
Inoue et al. 1998 16 Floor or Mouth HDR EBRT 30-40 Gy + BT 36-48 Gy @6 94
41 LDR Au Gy
198
EBRT 30-40 Gy + BT 65-85 Gy 69
Matsumoto et al. 2013 67 Tongue HDR EBRT 20 Gy + BT 50 Gy 94 88.7
[36]
Khalilur et al. 2011 125 Tongue LDR 70 Gy 86
[37]
Vedasoundaram et al. 33 Bucal mucosa HDR BT only 38.5 Gy @3.5 Gy 92.3
[38]
2014 EBRT 50 Gy + BT 21 Gy @3.5 Gy
[39]
Lee et al. 2014 16 Oral HDR BT only 50 84 (3-year) 70
cavity Gy @5 Gy
EBRT 50 Gy +BT 35 Gy @5 Gy
Tuček et al. 2014 20 Tongue HDR BT only 54 gy @3 Gy 85 75
[40]
[25]
Oota et al. 2006 433 Tongue LDR BT only 70 Gy 85.6
EBRT 35 Gy + BT 60 Gy
[41]
Pernot et al. 1996 552 Tongue LDR BT only 66 - 75 Gy 90.5 71.5
207 FOM
[42]
Lefebvre et al. 1994 429 OC LDR BT only 66 Gy 90
[43]
Mazeron et al. 1991 279 Tongue & FOM LDR BT only 60-70 Gy 87-93
[44]
Marsiglia et al. 2002 160 FOM LDR 88-93 76
[45]
Dearnaley et al. 1991 149 Tongue & FOM LDR BT only 90
Fujita et al. [46] 1999 207 Tongue LDR EBRT 30 Gy + BT 50-60 Gy 82.2
BT only 65-70 Gy
[27]
Bachaud et al. 1994 94 Tongue LDR EBRT 48 Gy + BT 26 Gy 61
& FOM BT only 66 Gy
Ihara et al. 2005 117 Tongue LDR EBRT 30 Gy + BT 65 Gy 59.2 54
[47]
BT only 70 Gy
@: dose per fraction when HDR is used. LDR: low dose rate; HDR: high dose rate; EBRT: external beam radiotherapy; BT: brachytherapy; OC: oral cavity;
FOM: floor of mouth; NS: no shown
[21]
uniformity of dose and tumor control. Table 1 summarizes using accelerated fractionation radiotherapy.
[20]
the results of selected series of OCSCC patients treated with
radical BT with or without EBRT. [12,22-47] In the case of floor of Two meta-analyses of randomized trials [48,49] comparing
mouth stage cT1 local control is 93-95% and 72-88% for stage conventional fractionation EBRT (CF-EBRT) against modified
cT2. Local control in cancer of mobile tongue is achieved in fractionation EBRT (MF-EBRT) were published. Bourhis et
79-97% for stage I and 65-95% for stage II. al. analyzes all clinical trials for all locations of the head
[48]
and neck (12.6% of cases OCSCC), however data are presented
Stages III-IV separately depending on location; Glenny et al. examined
[49]
Usually the treatment of advanced cancer of OCSCC has been
included in the group of “advanced head and neck cancer” trials for oral cavity and oropharynx cancer only.
(AHNC) because of this the indications, techniques and results [48]
from clinical trials are fully applicable. Bourhis et al. found a statistically significant benefit in
terms of overall survival (OS) HR = 0.92 in favor of MF-EBRT
Radiotherapy alone as well as an improvement in locoregional control (LRC) HR =
Modification of EBRT fractionation allows to intensify 0.82. Hyperfractionated EBRT was also significantly better in
radiation dose by means of two way: (a) increase in the total terms of OS than accelerated EBRT, with an absolute benefit
dose with hyperfractionation; and (b) shorten the duration of of 8% at 5 years.
160 Plast Aesthet Res || Volume 3 || May 25, 2016