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EL-Sabawi et al.                                                                                                                                                          Restoration of failed breast reconstruction

           causes of failure for the new flap. Previously cited   DECLARATIONS
           considerations for attempting microsurgical free flap
           reconstruction in the setting of prior free flap failure   Authors’ contributions
           include reassessment of the preoperative preparations,   Conception and design of review, performed literature
           flap choice, the recipient vessels and anastomotic   search protocol, data collection, drafting of manuscript,
           technique, the patient’s coagulability and potential   final revisions, and final approval of manuscript: B. EL-
           for thrombosis, the appropriateness of intraoperative   Sabawi
           positioning, the postoperative care, and the surgeon’s   Design of search protocol, study selection, review
           own level of experience [34] . Full blood and coagulation   of data, data analysis and interpretation, drafting
           tests with consultation of hematologist may also be   of manuscript, final revisions and final approval of
           required, particularly in those patients without evidence   manuscript: A.C. Howell
           of obvious technical problem as the cause of flap   Design of review, study selection, data interpretation,
                             [8]
           failure. Hamdi et al.  reported underlying hematologic   drafting of manuscript, final revisions, and final
           disorders in 3 out of 14 patients who underwent    approval of manuscript: K.M. Patel
           tertiary breast reconstruction after failed free flap
           reconstruction. Two of these patients went on to have   Financial support and sponsorship
           successful breast restoration with the use of a second   None.
           free flap and the other patient underwent successful
           implant reconstruction. This suggests that with proper   Conflicts of interest
           medical management, successful microsurgical       There are no conflicts of interest.
           restoration in these patients may be attained.
                                                              Patient consent
           This is the first systematic review to evaluate the   Not applicable.
           literature and consolidate the available data concerning
           autogenous tissue transfer to salvage unsuccessful   Ethics approval
           breast reconstruction. However, there are several   Not applicable.
           inherent limitations in this systematic review, including
           retrospective study design and the biases within each
           of the studies included. Inconsistently reported data and   REFERENCES
           scarce reporting of patient comorbidities also limited
           the findings of this review. The majority of current   1.   Wilkins EG, Cederna PS,  Lowery JC, Davis JA, Kim HM, Roth
           studies report outcomes from a single institution,    RS, Goldfarb S, Izenberg PH, Houin HP, Shaheen KW. Prospective
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                                                                 Hamdi M, Casaer B, Andrades P, Thiessen F, Dancey A, D’Arpa S,
           with tertiary reconstruction, stressing the importance   Van Landuyt K. Salvage (tertiary) breast reconstruction after implant
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