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vonderEmbse et al. Neuroimmunol Neuroinflammation 2020;7:345-59 I http://dx.doi.org/10.20517/2347-8659.2019.29 Page 357

Laboratory for Alzheimer’s and Neurodegenerative Diseases Research, our funding source, for transgenic
mouse accessibility, as well as the East Carolina University Department of Comparative Medicine for their
excellent husbandry and care of our animals.

Authors’ contributions
Made substantial contributions to the conception and design of the study: vonderEmbse AN, DeWitt JC
Assisted with technical expertise and dissections: vonderEmbse AN, Hu Q
Performed immunohistochemistry: vonderEmbse AN
Performed data analysis and interpretation: vonderEmbse AN
Provided administrative, technical, and material support: DeWitt JC
Involved in the writing and editing of the manuscript: vonderEmbse AN, DeWitt JC
Discussed the results and commented on the manuscript: vonderEmbse AN, Hu Q, DeWitt JC

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by the Harriet and John Wooten Laboratory for Alzheimer’s and Neurodegenerative
Diseases Research (https://www.ecu.edu/cs-dhs/wootenlab/). The funding body provided access to the
3xTgAD transgenic and wildtype mice used in the study.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
All handling and experimental manipulations were carried out in accordance with procedures approved by
the East Carolina University Institutional Animal Care and Use Committee (IACUC), and were conducted
in accordance with the ARRIVE guidelines and the National Institutes of Health guide for the care and use
of laboratory animals (NIH publication No. 8023, revised 1978).

Consent for publication
Not applicable.

Copyright
© The Author(s) 2020.

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