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Figure 9. BIRT377 treatment did not result in systemic immune changes. (A-J) Spleens were collected from the same mice used in
Figure 2B and analyzed for inflammatory cytokines. Splenic cytokine and chemokine protein levels were similar regardless of surgical
manipulation, treatment, or sex. n = 6 in each group
changes observed in discrete regions involved in the pain pathway (SCN, DRGs and LSC) are exceedingly
localized such that detection from the systemic pool of immune cells is not measurable. More likely, these
