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Marcet et al. Neuroimmunol Neuroinflammation 2017;4:82-92 Neuroimmunology and
DOI: 10.20517/2347-8659.2017.07
Neuroinflammation

www.nnjournal.net
Topic: Stroke Open Access

When friend turns foe: central and

peripheral neuroinflammation in central

nervous system injury

Paul Marcet, Nicole Santos, Cesar V. Borlongan

Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of
Medicine, Tampa, FL 33612, USA.
Correspondence to: Prof. Cesar V. Borlongan, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair,
University of South Florida Morsani College of Medicine, MDC 78, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA.
E-mail: cborlong@health.usf.edu
How to cite this article: Marcet P, Santos N, Borlongan CV. When friend turns foe: central and peripheral neuroinflammation in central nervous
system injury. Neuroimmunol Neuroinflammation 2017;4:82-92.

Prof. Cesar V. Borlongan is a Distinguished Professor, Vice-Chairman for Research, and Director of USF Morsani
College of Medicine’s Center of Excellence for Aging and Brain Repair. His highly innovative translational “bench
to clinic” research has led to FDA-approved clinical trials of cell transplantation in CNS disorders. He is an author
of > 370 peer-reviewed publications. He is funded by and a regular reviewer for NIH, DOD, and VA. He was
the President-Elect of American Society for Neural Therapy and Repair, and International Placenta Stem Cell
Society, and is an elected Fellow of AAAS and AIMBE. He was featured in The Lancet in 2008.

ABSTRACT
Article history: Injury to the central nervous system (CNS) is common, and though it has been well studied,
Received: 24-01-2017 many aspects of traumatic brain injury (TBI) and stroke are poorly understood. TBI and stroke
Accepted: 24-04-2017 are two pathologic events that can cause severe, immediate impact to the neurostructure and
Published: 17-05-2017 function of the CNS, which has been recognized recently to be exacerbated by the body’s
own immune response. Although the brain damage induced by the initial trauma is most
Key words: likely unsalvageable, the secondary immunologic deterioration of neural tissue gives ample
Head trauma, opportunity for therapeutic strategists seeking to mitigate TBI’s secondary detrimental effects.
inflammatory response, The purpose of this paper is to highlight the cell death mechanisms associated with CNS
secondary cell death, injury with special emphasis on inflammation. The authors discuss sources of inflammation,
central nervous system, and introduce the role of the spleen in the systemic response to inflammation after CNS injury.
spleen,
systemic

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