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Lai et al. Neuroimmunol Neuroinflammation 2017;4:179-87 Neuroimmunology and
DOI: 10.20517/2347-8659.2017.29
Neuroinflammation

www.nnjournal.net
Original Article Open Access

Peripheral NK and B regulatory cell frequencies

are altered with symptomatic exacerbation in

generalized myasthenia gravis patients

1,2
2
1
3
1
1
Xiao-Yin Lai , Meng-Cui Gui , Jing Lin , Yue Li , Xuan Luo , Long-Xuan Li , Bi-Tao Bu 1
1 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
2 Department of Neurology, Gongli Hospital, Pudong New Area, Shanghai 200135, China.
3 Teaching and Research Office of Hygiene, 95890 Unit, Chinese People's Liberation Army, Wuhan 430000, Hubei, China.
Correspondence to: Dr. Bi-Tao Bu, Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology, 1095 Jiefang Ave., Wuhan 430030, Hubei, China. E-mail: bubitao@tjh.tjmu.edu.cn; Dr. Long-Xuan Li, Department of Neurology, Gongli
Hospital, 219 Miaopu Road, Pudong New Area, Shanghai 200135, China. E-mail: Longxuanlee2006@yahoo.com
How to cite this article: Lai XY, Gui MC, Lin J, Li Y, Luo X, Li LX, Bu BT. Peripheral NK and B regulatory cell frequencies are altered with
symptomatic exacerbation in generalized myasthenia gravis patients. Neuroimmunol Neuroinflammation 2017;4:179-87.
Dr. Bi-Tao Bu is a professor of Neurology Department, Tongji Hospital, Huazhong University of Science and
Technology (HUST) in China. He had been educated at Hunan Medical College and Tongji Medical College of
HUST respectively. He also had been trained at University of Washington for 2 years and at University of California
at Davies for 1 year. He has been devoted to the clinical and basic studies on myasthenia gravis, inflammatory
myopathies and neuromyelitis optica spectrum disorder. His study has been sponsored by Natural Science
Foundation of China and Sino-German Joint Education Foundation. He is the member of Chinese Medical Society,
Chinese Immunology Society, and American Society for Neurosciences.

Dr. Long-Xuan Li currently serves as the professor and director in the Department of Neurology in Gongli Hospital,
Shanghai. He is the Doctoral Supervisor of The Second Military Medical University and was awarded with the
100-Talents Program of the Shanghai Municipal Health Bureau in 2017. He graduated with a doctorate degree in
Tongji Medical College of Huazhong University of Science and Technology in 2003, and further got postdoctoral
trainings at VA Medical Center of Kansas City, MO and the Scripps Research Institute, CA during 2006-2010.
He also got clinical training at Cleveland Clinic, OH in 2015, and worked as a Visiting Scholar at Mayo Clinic,
FL in 2017. He has nearly twenty years of experiences in practicing clinical neurology with focus on stroke and
neurodegenerative diseases.
ABSTRACT

Article history: Aim: Myasthenia gravis (MG) is an autoimmune disease, in which immunotherapy can
Received: 20 Jun 2017 improve symptoms for a period, but the majority of patients still experience symptomatic
Accepted: 24 Jul 2017 fluctuation or develop myasthenic crisis. This study aimed to explore the relationship between
Published: 18 Sep 2017 frequency of peripheral lymphocyte subsets and myasthenia gravis disease stage. Methods:
The percentages of B regulatory (Breg) cells and natural killer (NK) cells in the peripheral

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