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for decreasing incidence of cerebral aneurysm rupture. Stroke   change in ferumoxytol‑enhanced magnetic resonance imaging signal
              2011;42:3156‑62.                                    suggests unstable human cerebral aneurysm: a pilot study. Stroke
           16.  Xue J, Hua YN, Xie ML, Gu ZL. Aspirin inhibits MMP‑9 mRNA   2012;43:3258‑65.
              expression and release via the PPARalpha/gamma and COX‑2/  21.  Hasan  DM, Chalouhi  N, Jabbour  P, Magnotta  VA, Kung  DK,
              mPGES‑1‑mediated pathways in macrophages derived from   Young WL. Imaging aspirin effect on macrophages in the wall
              THP‑1 cells. Biomed Pharmacother 2010;64:118‑23.    of human cerebral aneurysms using ferumoxytol‑enhanced MRI:
           17.  Lu M, Cohen MH, Rieves D, Pazdur R. FDA report: ferumoxytol   preliminary results. J Neuroradiol 2013;40:187‑91.
              for intravenous iron therapy in adult patients with chronic kidney   22.  Hasan  DM, Chalouhi  N,  Jabbour  P, Dumont  AS,  Kung  DK,
              disease. Am J Hematol 2010;85:315‑9.                Magnotta VA, Young WL, Hashimoto T, Richard Winn H, Heistad D.
           18.  Williams JB, Ye Q, Hitchens TK, Kaufman CL, Ho C. MRI detection   Evidence that acetylsalicylic acid attenuates inflammation in the
              of macrophages labeled using micrometer‑sized iron oxide particles.   walls of human cerebral aneurysms: preliminary results. J Am Heart
              J Magn Reson Imaging 2007;25:1210‑8.                Assoc 2013;2:e000019.
           19.  Hasan DM, Mahaney KB, Magnotta VA, Kung DK, Lawton MT,
              Hashimoto T, Winn HR, Saloner D, Martin A, Gahramanov S,
              Dosa  E, Neuwelt  E, Young  WL. Macrophage imaging within
              human cerebral aneurysms wall using ferumoxytol‑enhanced   Cite  this  article  as:  Levitt  MR,  Kalani  MY,  Moon  K,  McDougall  CG,
                                                               Albuquerque FC. Advances in the imaging of cerebral aneurysm inflammation.
              MRI: a pilot study.  Arterioscler Thromb Vasc Biol 2012;32:   Neuroimmunol Neuroinflammation 2015;2(2):51-4.
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           20.  Hasan  D, Chalouhi  N, Jabbour  P, Dumont  AS, Kung  DK,   Source of Support: Nil. Conflict of Interest: No.
              Magnotta VA, Young WL, Hashimoto T, Winn HR, Heistad D. Early   Received: 13-08-2014; Accepted: 01-09-2014



































































            54                                               Neuroimmunol Neuroinflammation | Volume 2 | Issue 2 | April 15, 2015
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