Page 250 - Read Online

concentrations in depressed patients receiving ECT. Am J Psychiatry Caruncho HJ. Reelin is preferentially expressed in neurons
2003;160:577‑9. synthesizing gamma‑aminobutyric acid in cortex and hippocampus
27. Gabbay V, Mao X, Klein RG, Ely BA, Babb JS, Panzer AM, Alonso CM, of adult rats. Proc Natl Acad Sci U S A 1998;95:3221‑6.
Shungu DC. Anterior cingulate cortex gamma‑aminobutyric acid 47. Fatemi SH, Emamian ES, Kist D, Sidwell RW, Nakajima K,
in depressed adolescents: relationship to anhedonia. Arch Gen Akhter P, Shier A, Sheikh S, Bailey K. Defective corticogenesis
Psychiatry 2012;69:139‑49. and reduction in Reelin immunoreactivity in cortex and
28. Martin DL, Martin SB, Wu SJ, Espina N. Cofactor interactions and hippocampus of prenatally infected neonatal mice. Mol Psychiatry
the regulation of glutamate decarboxylase activity. Neurochem Res 1999;4:145‑54.
1991;16:243‑9. 48. Fatemi SH, Earle JA, McMenomy T. Reduction in Reelin
29. Roberts E, Frankel S. Glutamic acid decarboxylase in brain. J Biol immunoreactivity in hippocampus of subjects with schizophrenia,
Chem 1951;188:789‑95. bipolar disorder and major depression. Mol Psychiatry
30. Roberts E, Frankel S. Gamma‑aminobutyric acid in brain: its 2000;5:654‑63, 571.
formation from glutamic acid. J Biol Chem 1950;187:55‑63. 49. Fatemi SH, Stary JM, Halt AR, Realmuto GR. Dysregulation of
31. Awapara J. Occurrence of free gamma‑aminobutyric acid in brain and Reelin and Bcl‑2 proteins in autistic cerebellum. J Autism Dev Disord
its formation from L‑glutamic acid. Tex Rep Biol Med 1950;8:443‑7. 2001;31:529‑35.
32. Reetz A, Solimena M, Matteoli M, Folli F, Takei K, De Camilli P. 50. Fatemi SH, Kroll JL, Stary JM. Altered levels of Reelin and its
GABA and pancreatic beta‑cells: colocalization of glutamic acid isoforms in schizophrenia and mood disorders. Neuroreport
decarboxylase (GAD) and GABA with synaptic‑like microvesicles 2001;12:3209‑15.
suggests their role in GABA storage and secretion. EMBO J 51. Fatemi SH. Reelin mutations in mouse and man: from reeler mouse
1991;10:1275‑84. to schizophrenia, mood disorders, autism and lissencephaly. Mol
33. Sorenson RL, Garry DG, Brelje TC. Structural and functional Psychiatry 2001;6:129‑33.
considerations of GABA in islets of Langerhans. Beta‑cells and 52. Fatemi SH. The role of Reelin in pathology of autism. Mol Psychiatry
nerves. Diabetes 1991;40:1365‑74. 2002;7:919‑20.
34. Jun HS, Khil LY, Yoon JW. Role of glutamic acid decarboxylase 53. Fatemi SH, Halt AR, Stary JM, Kanodia R, Schulz SC, Realmuto GR.
in the pathogenesis of type 1 diabetes. Cell Mol Life Sci Glutamic acid decarboxylase 65 and 67 kDa proteins are
2002;59:1892‑901. reduced in autistic parietal and cerebellar cortices. Biol Psychiatry
35. Erlander MG, Tillakaratne NJ, Feldblum S, Patel N, Tobin AJ. 2002;52:805‑10.
Two genes encode distinct glutamate decarboxylases. Neuron 54. Fatemi SH, Stary JM, Egan EA. Reduced blood levels of Reelin as
1991;7:91‑100. a vulnerability factor in pathophysiology of autistic disorder. Cell
36. Kaufman DL, Houser CR, Tobin AJ. Two forms of the Mol Neurobiol 2002;22:139‑52.
gamma‑aminobutyric acid synthetic enzyme glutamate decarboxylase 55. Weeber EJ, Beffert U, Jones C, Christian JM, Forster E, Sweatt JD,
have distinct intraneuronal distributions and cofactor interactions. Herz J. Reelin and ApoE receptors cooperate to enhance
J Neurochem 1991;56:720‑3. hippocampal synaptic plasticity and learning. J Biol Chem
37. Soghomonian JJ, Laprade N. Glutamate decarboxylase (GAD67 2002;277:39944‑52.
and GAD65) gene expression is increased in a subpopulation 56. Knable MB, Barci BM, Bartko JJ, Webster MJ, Torrey EF. Molecular
of neurons in the putamen of parkinsonian monkeys. Synapse abnormalities in the major psychiatric illnesses: classification and
1997;27:122‑32. regression tree (CRT) analysis of post‑mortem prefrontal markers.
38. Asada H, Kawamura Y, Maruyama K, Kume H, Ding RG, Kanbara N, Mol Psychiatry 2002;7:392‑404.
Kuzume H, Sanbo M, Yagi T, Obata K. Cleft palate and decreased 57. Heckers S, Stone D, Walsh J, Shick J, Koul P, Benes FM. Differential
brain gamma‑aminobutyric acid in mice lacking the 67‑kDa hippocampal expression of glutamic acid decarboxylase 65 and 67
isoform of glutamic acid decarboxylase. Proc Natl Acad SciU S A messenger RNA in bipolar disorder and schizophrenia. Arch Gen
1997;94:6496‑9. Psychiatry 2002;59:521‑9.
39. Asada H, Kawamura Y, Maruyama K, Kume H, Ding R, Ji FY, 58. Woo TU, Walsh JP, Benes FM. Density of glutamic acid
Kanbara N, Kuzume H, Sanbo M, Yagi T, Obata K. Mice lacking the decarboxylase 67 messenger RNA‑containing neurons that express
65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain the N‑methyl‑D‑aspartate receptor subunit NR2A in the anterior
normal levels of GAD67 and GABA in their brains but are susceptible cingulate cortex in schizophrenia and bipolar disorder. Arch Gen
to seizures. Biochem Biophys Res Commun 1996;229:891‑5. Psychiatry 2004;61:649‑57.
40. Martin DL, Rimvall K. Regulation of gamma‑aminobutyric acid 59. Kalkman HO, Loetscher E. GAD (67): the link between the
synthesis in the brain. J Neurochem 1993;60:395‑407. GABA‑deficit hypothesis and the dopaminergic‑ and glutamatergic
41. Karolewicz B, Maciag D, O’Dwyer G, Stockmeier CA, theories of psychosis. J Neural Transm 2003;110:803‑12.
Feyissa AM, Rajkowska G. Reduced level of glutamic acid 60. Moersch FP, Woltman HW. Progressive fluctuating muscular
decarboxylase‑67 kDa in the prefrontal cortex in major depression. rigidity and spasm (“stiff‑man” syndrome); report of a case and
Int J Neuropsychopharmacol 2010;13:411‑20. some observations in 13 other cases. Proc Staff Meet Mayo Clin
42. Fatemi SH, Stary JM, Earle JA, Araghi‑Niknam M, Eagan E. 1956;31:421‑7.
GABAergic dysfunction in schizophrenia and mood disorders as 61. Levy LM, Dalakas MC, Floeter MK. The stiff‑person syndrome:
reflected by decreased levels of glutamic acid decarboxylase 65 an autoimmune disorder affecting neurotransmission of
and 67 kDa and Reelin proteins in cerebellum. Schizophr Res gamma‑aminobutyric acid. Ann Intern Med 1999;131:522‑30.
2005;72:109‑22. 62. Solimena M, Folli F, Denis‑Donini S, Comi GC, Pozza G, De
43. Labarca R, Silva H, Jerez S, Ruiz A, Renterias P, Ogalde C, Bustos G. Camilli P, Vicari AM. Autoantibodies to glutamic acid decarboxylase
Effects of haloperidol on CSF glutamate levels in drug‑naive in a patient with stiff‑man syndrome, epilepsy, and type I diabetes
schizophrenic patients. Schizophr Res 1995;16:83‑5. mellitus. N Engl J Med 1988;318:1012‑20.
44. Tortorella A, Monteleone P, Fabrazzo M, Viggiano A, De Luca L, 63. Ellis TM, Atkinson MA. The clinical significance of an autoimmune
Maj M. Plasma concentrations of amino acids in chronic response against glutamic acid decarboxylase. Nat Med
schizophrenics treated with clozapine. Neuropsychobiology 1996;2:148‑53.
2001;44:167‑71. 64. Dinkel K, Meinck HM, Jury KM, Karges W, Richter W. Inhibition of
45. Levine J, Panchalingam K, Rapoport A, Gershon S, McClure RJ, gamma‑aminobutyric acid synthesis by glutamic acid decarboxylase
Pettegrew JW. Increased cerebrospinal fluid glutamine levels in autoantibodies in stiff‑man syndrome. Ann Neurol 1998;44:194‑201.
depressed patients. Biol Psychiatry 2000;47:586‑93. 65. Musselman DL, Betan E, Larsen H, Phillips LS. Relationship of
46. Pesold C, Impagnatiello F, Pisu MG, Uzunov DP, Costa E, Guidotti A, depression to diabetes types 1 and 2: epidemiology, biology, and

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