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CONCLUSION structural networks characterize major depressive disorder: a
connectome analysis. Biol Psychiatry 2014;76:567‑74.
13. Lai CH, Wu YT. Alterations in white matter micro‑integrity
White matter abnormalities may be proposed as of the superior longitudinal fasciculus and anterior thalamic
biological markers of poor outcome in patients with radiation of young adult patients with depression. Psychol Med
MDD also triggering suicidal behavior. The presence of 2014;44:2825‑32.
WMHs may be used for grouping and closely monitoring 14. Song YJ, Korgaonkar MS, Armstrong LV, Eagles S, Williams LM,
those patients with more severe illness impairments Grieve SM. Tractography of the brainstem in major depressive
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requiring more targeted interventions. However, 15. Olvet DM, Peruzzo D, Thapa‑Chhetry B, Sublette ME, Sullivan GM,
further prospective studies are needed to more deeply Oquendo MA, Mann JJ, Parsey RV. A diffusion tensor imaging study
investigate differential outcome trajectories as well as of suicide attempters. J Psychiatr Res 2014;51:60‑7.
to develop tailored treatment strategies in patients with 16. Lopez‑Larson M, King JB, McGlade E, Bueler E, Stoeckel A,
MDD. This field is rapidly expanding, and we are only Epstein DJ, Yurgelun‑Todd D. Enlarged thalamic volumes and
increased fractional anisotropy in the thalamic radiations in veterans
at the beginning of this interesting journey. A better with suicide behaviors. Front Psychiatry 2013;4:83.
understanding of the biological processes involved 17. Yurgelun‑Todd DA, Bueler CE, McGlade EC, Churchwell JC,
in the progression of WM alterations is undoubtedly Brenner LA, Lopez‑Larson MP. Neuroimaging correlates of
necessary. traumatic brain injury and suicidal behavior. J Head Trauma Rehabil
2011;26:276‑89.
18. Jia Z, Wang Y, Huang X, Kuang W, Wu Q, Lui S, Sweeney JA,
Financial support and sponsorship Gong Q. Impaired frontothalamic circuitry in suicidal patients with
Nil. depression revealed by diffusion tensor imaging at 3.0 T. J Psychiatry
Neurosci 2014;39:170‑7.
Conflicts of interest 19. LeWinn KZ, Connolly CG, Wu J, Drahos M, Hoeft F, Ho TC,
There are no conflicts of interest. Simmons AN, Yang TT. White matter correlates of adolescent
depression: structural evidence for frontolimbic disconnectivity.
J Am Acad Child Adolesc Psychiatry 2014;53:899‑909, 909.e1‑7.
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